Version: 8.0.0
Date: Tue Jan 28 2025
Dmrt2
Mus musculusMGI:1330307
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dmrt2

Species
Mus musculus
Symbol
Dmrt2
Name
doublesex and mab-3 related transcription factor 2
Synonyms
  • Terra
  • terra homolog (zebrafish)
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and long bone. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12322
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensDMRT210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusDmrt29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisdmrt29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriodmrt2a10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Danio reriodmrt2b3 of 10NoYes☐ ☐☐☐☑☐☑☐☐ ☑
Drosophila melanogasterdmrt11E3 of 9YesYes☑ ☐☐☐☑☐☐☑☐  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Dmrta2157434273 of 9☑☐☐☐☐☐☑☑☐ 
Dmrt3248536273 of 9☑☐☐☐☐☐☑☑☐ 
Dmrt1347238263 of 9☑☐☐☐☐☐☑☑☐ 
Dmrtc2447536263 of 9☑☐☐☐☐☐☑☑☐ 
Dmrtb1544234253 of 9☑☐☐☐☐☐☑☑☐ 
Dmrtc1b633432202 of 9☑☐☐☐☐☐☑☐☐ 
Dmrta1715351463 of 9☑☐☐☐☐☐☑☑☐ 
Dmrtc1a816240252 of 9☑☐☐☐☐☐☑☐☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal caudal vertebrae morphology
abnormal cervical vertebrae morphology
abnormal dermomyotome development
abnormal lumbar vertebrae morphology
abnormal myotome development
abnormal myotome morphology
abnormal pulmonary alveolus morphology
abnormal sacral vertebrae morphology
abnormal sclerotome morphology
abnormal somite development
Showing 1 - 10 of 25 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Dmrt2em1Smoc
    • Dmrt2em1(flox)Smoc
    		allele
    Dmrt2em2Cya
    • Dmrt2em1flox
    		allele
    Dmrt2em14Gpt
    • Dmrt2em14Cd1406in1
    		allele
    Dmrt2em1Gpt
    • Dmrt2em1Cflox
    		allele
    Dmrt2tm1Rjo
    • Dmrt2-
    		allele
    		Yes
    NC_000085.7:g.25649830C>Tvariant
    SNP
    • 5 prime UTR variant
    NC_000085.7:g.25651950G>Tvariant
    SNP
    • intron variant
    NC_000085.7:g.25651969C>Tvariant
    SNP
    • intron variant
    NC_000085.7:g.25652555A>Gvariant
    SNP
    • intron variant
    NC_000085.7:g.25652906A>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 189 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Dmrt2tm1Rjo/Dmrt2tm1Rjo [background:] involves: 129S7/SvEvBrd * C57BL/6
    • abnormal caudal vertebrae morphology
    • abnormal cervical vertebrae morphology
    		MGI
    Showing 1 - 1 of 1 rows
    per page

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    25 interactor genes based on 33 annotations
    Dmrt2 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ActbMus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Actc1Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Bclaf1Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Ccdc18Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Ccdc18Mus musculus
    protein
    • biochemical
    		PMID:32325033
    protein
    		Ddx21Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Fxr1Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Fxr2Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    protein
    		Hnrnpa1Mus musculus
    protein
    • pull down
    		PMID:20975687
    protein
    		Hnrnpa1Mus musculus
    protein
    • affinity chromatography technology
    		PMID:20975687
    Showing 1 - 10 of 33 rows
    per page

    Genetic Interactions

    No data available