Gene

Camkk1

Species
Mus musculus
Symbol
Camkk1
Name
calcium/calmodulin-dependent protein kinase kinase 1, alpha
Synonyms
  • AI846603
  • CaMKKalpha
Biotype
protein coding gene
Automated Description
Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and grossly normal but exhibit context fear deficits during both conditioning and long-term follow-up testing. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24346
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCAMKK110 of 10YesYes  
Rattus norvegicusCamkk19 of 9YesYes   
Xenopus tropicaliscamkk19 of 9YesYes   
Danio reriocamkk1a9 of 10YesYes  
Danio reriocamkk1b5 of 10NoYes  
Drosophila melanogasterCG176986 of 9YesYes   
Caenorhabditis elegansckk-18 of 9YesYes   
Saccharomyces cerevisiaeSAK12 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Camkk2149876616 of 9 
Camk2b244645282 of 9 
Stk11341745302 of 9 
Camk2g440647302 of 9 
Camk1542044282 of 9 
Pskh1642444272 of 9 
Camk1d739448282 of 9 
Camk2d838446302 of 9 
Camk2a936948312 of 9 
Pnck1037146282 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal contextual conditioning behavior
Showing 1 - 1 of 1 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Camkk1tm1.1Armallele
Camkk1em1Gpt
  • Camkk1em1Cflox
allele
Camkk1em8Gpt
  • Camkk1em8Cd5019
allele
Camkk1tm1Tchallele
Yes
NC_000077.7:g.72917159G>Tvariant
SNP
  • intron variant
NC_000077.7:g.72923505T>Cvariant
SNP
  • intron variant
NC_000077.7:g.72922252C>Gvariant
SNP
  • intron variant
NC_000077.7:g.72922279A>Gvariant
SNP
  • intron variant
NC_000077.7:g.72922922T>Cvariant
SNP
  • intron variant
NC_000077.7:g.72910832T>Cvariant
SNP
  • intron variant
Showing 1 - 10 of 603 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Camkk1tm1Tch/Camkk1tm1Tch [background:] involves: 129X1/SvJ * C57BL/6
  • abnormal contextual conditioning behavior
MGI
Camkk1tm1Tch/Camkk1tm1Tch Camkk2tm1Tch/Camkk2tm1Tch [background:] involves: 129X1/SvJ
  • abnormal axon morphology
  • abnormal dendrite morphology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
72.910M72.912M72.914M72.916M72.918M72.920M72.922M72.924M72.926M72.928M72.930M72.932M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
Camkk1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Akt1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Camk1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Camk1dMus musculus
protein
  • biochemical
PMID:32325033
protein
Nos2Mus musculus
protein
  • fluorescence technology
PMID:15556629
protein
YwhabMus musculus
protein
  • biochemical
PMID:32325033
protein
YwhahMus musculus
protein
  • biochemical
PMID:32325033
protein
YwhaqMus musculus
protein
  • biochemical
PMID:32325033
Showing 1 - 7 of 7 rows
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Genetic Interactions

No data available