Gene

Cers5

Species
Mus musculus
Symbol
Cers5
Name
ceramide synthase 5
Synonyms
  • 2310081H14Rik
  • AU045339
Biotype
protein coding gene
Automated Description
Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Acts upstream of or within sphingolipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut. Orthologous to human CERS5 (ceramide synthase 5).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12560
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCERS59 of 10YesYes  
Rattus norvegicusCers59 of 9YesYes   
Xenopus tropicaliscers55 of 9YesYes   
Danio reriocers58 of 10YesYes  
Drosophila melanogasterschlank9 of 9YesYes   
Caenorhabditis eleganshyl-19 of 9YesYes   
Caenorhabditis eleganshyl-28 of 9NoYes   
Saccharomyces cerevisiaeLAG16 of 9YesNo   
Saccharomyces cerevisiaeLAC16 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cers6138377617 of 9 
Cers4239959407 of 9 
Cers2337659417 of 9 
Cers3437856417 of 9 
Cers1534739263 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal bone structure
abnormal motor coordination/balance
decreased bone mineral content
decreased bone mineral density
decreased exploration in new environment
decreased thigmotaxis
increased circulating sodium level
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Saccharomyces cerevisiaeLAG1
is implicated inhepatocellular carcinoma
  • ISS
Saccharomyces cerevisiaeLAG1
is implicated insteatotic liver disease
  • ISS
Saccharomyces cerevisiaeLAG1
is implicated intype 2 diabetes mellitus
  • ISS
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Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
99.635M99.640M99.645M99.650M99.655M99.660M99.665M99.670M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Cers5tm2b(KOMP)Mbpallele
Yes
Cers5tm2a(KOMP)Mbpallele
Cers5em1Gpt
  • Cers5em1Cflox
allele
Cers5tm1.1Mhoc
  • Cers5lacZ
allele
Cers5tm1a(KOMP)Mbpallele
Cers5em2Btlrallele with one associated variant
deletion
  • splice donor variant
Cers5em1Btlrallele with one associated variant
deletion
  • splice donor variant
NC_000081.7:g.99636769C>Tvariant
SNP
  • intron variant
NC_000081.7:g.99634873G>Tvariant
SNP
  • intron variant
NC_000081.7:g.99637827A>Gvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Cers5tm2b(KOMP)Mbp/Cers5tm2b(KOMP)Mbp [background:] B6N(Cg)-Cers5tm2b(KOMP)Mbp/J
  • abnormal bone structure
  • abnormal motor coordination/balance
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
99.635M99.640M99.645M99.650M99.655M99.660M99.665M99.670MENSMUST00000023762 (Cers5)ENSMUST00000109035 (Cers5)ENSMUST00000175876 (Cers5)ENSMUST00000176248 (Cers5)ENSMUST00000176627 (Cers5)ENSMUST00000176970 (Cers5)NM_028015.2 (Cers5)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Cers5 (Mmu)
cers5 (Dre)
schlank (Dme)
hyl-1 (Cel)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
Cers5 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CfdMus musculus
protein
  • affinity chromatography technology
PMID:30550785
protein
Ewsr1Mus musculus
protein
  • two hybrid
PMID:20211142
protein
Fndc5Mus musculus
protein
  • affinity chromatography technology
PMID:30550785
protein
Kctd13Mus musculus
protein
  • affinity chromatography technology
PMID:37142655
protein
Sertad1Mus musculus
protein
  • two hybrid
PMID:20211142
protein
Sting1Mus musculus
protein
  • proximity labelling technology
PMID:32554809
protein
Wwtr1Mus musculus
protein
  • two hybrid
PMID:20211142
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Genetic Interactions

No data available