Gene

Dek

Species
Mus musculus
Symbol
Dek
Name
DEK proto-oncogene
Synonyms
  • 1810019E15Rik
  • D13H6S231E
Biotype
protein coding gene
Automated Description
Predicted to enable histone binding activity. Acts upstream of or within regulation of double-strand break repair via nonhomologous end joining. Located in contractile muscle fiber and nucleus. Is expressed in several structures, including early conceptus; limb; oocyte; retina; and telencephalon. Orthologous to human DEK (DEK proto-oncogene).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit delayed development of DMBA- and TPA-induced papillomas. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13468
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensDEK10 of 10YesYes  
Rattus norvegicusDek9 of 9YesYes   
Xenopus tropicalisdek5 of 9YesYes   
Danio reriodek10 of 10YesYes  
Drosophila melanogasterDek7 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal tongue squamous epithelium morphology
decreased incidence of tumors by chemical induction
esophagus hyperplasia
increased incidence of tumors by chemical induction
increased squamous cell carcinoma incidence
premature death
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
47.240M47.242M47.244M47.246M47.248M47.250M47.252M47.254M47.256M47.258M47.260M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Dekem1Gpt
  • Dekem1Cflox
allele
Dekem3Cya
  • Dekem1
allele
Dekem2Cya
  • Dekem1flox
allele
Dektm1Siweallele
Yes
Dektm1.1Yhou
  • Dekfl
allele
Dekem1Cya
  • Dekem1
allele
NC_000079.7:g.47241093G>Avariant
SNP
  • intron variant
NC_000079.7:g.47241691A>Tvariant
SNP
  • intron variant
NC_000079.7:g.47241848T>Avariant
SNP
  • intron variant
NC_000079.7:g.47242039G>Avariant
SNP
  • missense variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(CAG-Dek)#Yhou
Mus musculusTg(tetO/CMV-Dek,-luc)317Siwe
Yes
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Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Dektm1Siwe/Dektm1Siwe [background:] involves: 129P2/OlaHsd
  • decreased incidence of tumors by chemical induction
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
47.240M47.242M47.244M47.246M47.248M47.250M47.252M47.254M47.256M47.258MENSMUST00000021807 (Dek)ENSMUST00000129352 (Dek)ENSMUST00000135278 (Dek)ENSMUST00000138401 (Dek)ENSMUST00000143933 (Dek)ENSMUST00000150652 (Dek)ENSMUST00000224150 (Dek)NM_025900.2 (Dek)XM_036157833.1 (Dek)XR_382230.3 (Dek)Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

13 interactor genes based on 13 annotations
Dek molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Atxn1Mus musculus
protein
  • affinity chromatography technology
PMID:30457570
protein
Ccnl1Mus musculus
protein
  • biochemical
PMID:32325033
protein
F13bMus musculus
protein
  • biochemical
PMID:32325033
protein
Fbxw7Mus musculus
protein
  • affinity chromatography technology
PMID:30783098
protein
Gpatch2Mus musculus
protein
  • biochemical
PMID:32325033
protein
Irf2bp2Mus musculus
protein
  • biochemical
PMID:32325033
protein
Macroh2a1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Phf14Mus musculus
protein
  • biochemical
PMID:32325033
protein
Tlx3Mus musculus
protein
  • two hybrid
PMID:20211142
protein
Twist1Mus musculus
protein
  • proximity labelling technology
PMID:33554859
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Genetic Interactions

No data available