Species

Mus musculus

Symbol

Fbxw7

Name

F-box and WD-40 domain protein 7

Synonyms

1110001A17Rik
AGO

Biotype

protein coding gene

Automated Description

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7).

MGI Description

PHENOTYPE: Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR19849

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	FBXW7	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Rattus norvegicus	Fbxw7	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Xenopus tropicalis	fbxw7	8 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☐
Danio rerio	fbxw7	9 of 10	Yes	Yes	☑ ☑☑☑☑☑☐☑☑ ☑
Drosophila melanogaster	ago	3 of 9	Yes	Yes	☑ ☐☐☐☐☑☐☐☑
Caenorhabditis elegans	sel-10	7 of 9	Yes	Yes	☐ ☑☑☑☑☑☐☑☑
Saccharomyces cerevisiae	CDC4	3 of 9	Yes	Yes	☐ ☑☐☐☑☐☐☑☐
Saccharomyces cerevisiae	MET30	3 of 9	Yes	Yes	☐ ☐☑☐☐☑☐☐☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Btrc	1	573	47	30	3 of 9	☑☐☐☐☐☑☐☑☐
Wdr64	2	885	31	16	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw11	3	450	53	33	3 of 9	☑☐☐☐☐☑☐☑☐
Wdr95	4	664	34	22	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw8	5	607	35	20	2 of 9	☑☐☐☐☐☐☐☑☐
Traf7	6	413	46	28	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw9	7	438	39	24	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw22	8	475	34	21	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw27	9	449	37	20	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw24	10	464	37	18	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw19	11	461	35	20	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw26	12	473	34	19	2 of 9	☑☐☐☐☐☐☐☑☐
Wdr86	13	382	38	26	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw16	14	463	34	19	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw20	15	430	39	18	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw21	16	466	33	19	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw17	17	454	32	20	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw28	18	432	34	19	2 of 9	☑☐☐☐☐☐☐☑☐
Plaa	19	347	40	26	2 of 9	☐☐☐☐☐☐☑☑☐
Fbxw13	20	433	30	21	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw15	21	420	32	18	2 of 9	☑☐☐☐☐☐☐☑☐
Wdr49	22	330	39	23	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw14	23	344	33	20	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw18	24	299	34	20	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxw25	25	218	36	22	2 of 9	☑☐☐☐☐☐☐☑☐
Fbxo16	26	157	43	26	2 of 9	☑☐☐☐☐☐☐☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

Phenotype Term

Annotation details

References

abnormal blood vessel morphology

View

PMID:14766969

abnormal brain development

View

Name	Type	Experimental condition	Modifier	References
Fbxw7^tm1Sje/Fbxw7^tm1Sje [background:] involves: 129S7/SvEvBrd * C57BL/6	genotype			PMID:14766969
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(Nes-cre)1Kln/0 [background:] involves: C57BL/6 * SJL	genotype			PMID:20935640

abnormal brain vasculature morphology

View

PMID:14672936

abnormal cerebellar foliation

View

PMID:21827743

abnormal cerebellum development

View

PMID:20935640

abnormal cerebellum fissure morphology

View

PMID:21827743

abnormal cerebral cortex morphology

View

PMID:20935640

abnormal cortical intermediate zone morphology

View

PMID:20935640

abnormal cortical plate morphology

View

PMID:20935640

abnormal embryonic/fetal subventricular zone morphology

View

PMID:20935640

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Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

Chr3:84722575...84886505 + (163.93 kb)

Assembly version

GRCm39

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category
Fbxw7^tm1Iaai	Fbw7^flox	allele	Yes
Fbxw7^tm1Sje	Fbw7^-	allele	Yes
Fbxw7^tm2.1Kei		allele
Fbxw7^tm2Kei	Fbxw7^F	allele
Fbxw7^tm1Iken	Fbxw7^LSL-R468C	allele	Yes
Fbxw7^tm1.1Iken	Fbxw7^R468C	allele	Yes
Fbxw7^em1Smoc	Fbxw7^{em1(flox)Smoc}	allele
Fbxw7^tm1.1Axbe	Fbxw7^f	allele	Yes
Fbxw7^tm1Itom	Fbxw7^fl(R482Q) Fbxw7^flox	allele	Yes
Fbxw7^{tm2a(EUCOMM)Wtsi}	Fbxw7^betageo	allele

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name	Associated Phenotypes	Source
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm2.1Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0 [background:] involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal Purkinje cell morphology small cerebellum	MGI
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun⁺ Tg(Nes-cre)1Kln/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal neuron apoptosis abnormal tectum morphology	MGI
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0 [background:] involves: 129P2/OlaHsd	abnormal Purkinje cell morphology abnormal cerebellum fissure morphology	MGI
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Notch1^tm1Agt/Notch1⁺ Tg(Nes-cre)1Kln/0 [background:] involves: 129 * C57BL/6 * SJL	abnormal neuron differentiation	MGI
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj/0 [background:] Not Specified	abnormal Purkinje cell morphology abnormal cerebellar foliation	MGI
Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(Nes-cre)1Kln/0 [background:] involves: C57BL/6 * SJL	abnormal brain development abnormal cerebellum development	MGI
Fbxw7^tm1.1Iken/Fbxw7⁺ [background:] involves: C57BL/6 * C57BL/6N	abnormal respiratory system physiology cleft palate	MGI
Fbxw7^tm1.1Kei/Fbxw7^tm1.1Kei [background:] involves: 129P2/OlaHsd * C57BL/6	abnormal vascular development prenatal lethality, complete penetrance	MGI
Fbxw7^tm1.2Axbe/Fbxw7^tm1.2Axbe [background:] Not Specified	embryonic lethality, complete penetrance	MGI
Fbxw7^tm1Iaai/Fbxw7^tm1Iaai Tg(Amh-cre)8815Reb/0 [background:] involves: 129 * C57BL/6 * C57BL/6J * FVB/N	abnormal Sertoli cell barrier morphology abnormal Sertoli cell morphology	MGI

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Sequence Feature Viewer

Genome location

Chr3:84722575...84886505 + (163.93 kb)

Assembly version

GRCm39

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

57 interactor genes based on 82 annotations

Fbxw7 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	Cdc16	Mus musculus	protein	affinity chromatography technology	biogrid:2614952	PMID:30783098
protein	CEBPA	Homo sapiens	protein	affinity chromatography technology	biogrid:682699	PMID:20534483
protein	CEBPA	Homo sapiens	protein	affinity chromatography technology	biogrid:682697	PMID:20534483
protein	CREB3L1	Homo sapiens	protein	affinity chromatography technology	biogrid:886854	PMID:23955342
protein	CREB3L1	Homo sapiens	protein	enzymatic study	biogrid:886858	PMID:23955342
protein	CREB3L1	Homo sapiens	protein	affinity chromatography technology	biogrid:1108030	PMID:23955342
protein	Creb3l1	Mus musculus	protein	affinity chromatography technology	biogrid:2521621	PMID:29472293
protein	CREB3L2	Homo sapiens	protein	affinity chromatography technology	biogrid:886856	PMID:23955342
protein	CREB3L2	Homo sapiens	protein	enzymatic study	biogrid:886857	PMID:23955342
protein	CREB3L2	Homo sapiens	protein	affinity chromatography technology	biogrid:1108031	PMID:23955342

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Genetic Interactions

Fbxw7 role	Fbxw7 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
unspecified role		Kras	Mus musculus	unspecified role		positive genetic interaction (sensu BioGRID)		biogrid:2878722	PMID:31748650
unspecified role		Pten	Mus musculus	unspecified role		synthetic haploinsufficiency (sensu BioGRID)		biogrid:693396	PMID:22513362

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