Gene

Irgm2

Species
Mus musculus
Symbol
Irgm2
Name
immunity-related GTPase family M member 2
Synonyms
  • AI481100
  • expressed sequence AI481100
Biotype
protein coding gene
Automated Description
Enables GTPase activity. Involved in several processes, including defense response to protozoan; negative regulation of non-canonical inflammasome complex assembly; and protein targeting to vacuolar membrane. Acts upstream of or within response to bacterium. Is active in Golgi membrane; cytosol; and vacuolar membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR32341
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensIRGM6 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Igtp141164516 of 9 
Irgm1240761466 of 9 
9930111J21Rik1341748313 of 9 
Gm12185441249313 of 9 
Gm5431539549313 of 9 
Gm4841640947283 of 9 
Irgc740148303 of 9 
F830016B08Rik841046283 of 9 
Tgtp2935253333 of 9 
Tgtp1935253333 of 9 
Iigp11037250283 of 9 
Ifi471131850343 of 9 
Iigp1c1230754333 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal coat appearance
abnormal lens morphology
abnormal skin morphology
abnormal startle reflex
absent vibrissae
decreased circulating serum albumin level
decreased thigmotaxis
increased susceptibility to parasitic infection
increased susceptibility to parasitic infection induced morbidity/mortality
Showing 1 - 9 of 9 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
58.092M58.094M58.096M58.098M58.100M58.102M58.104M58.106M58.108M58.110M58.112M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Irgm2tm1.1Jcrs
  • Irgm2flox
allele
Irgm2tm1.2Jcrsallele
Irgm2em2Myamallele
Irgm2em1Myam
  • Irgm2-M77a
allele
Yes
Irgm2em1Gpt
  • Irgm2em1Cflox
allele
Irgm2em3Gpt
  • Irgm2em3Cd4380
allele
Irgm2em1(IMPC)J
  • Irgm2em1J
allele
Yes
NC_000077.7:g.58101462C>Tvariant
SNP
  • intron variant
NC_000077.7:g.58102482T>Cvariant
SNP
  • intron variant
NC_000077.7:g.58099289A>Tvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Igtpem1Myam/Igtpem1Myam Irgm1em1Myam/Irgm1em1Myam Irgm2em2Myam/Irgm2em2Myam [background:] C57BL/6-Irgm1em1Myam Igtpem1Myam Irgm2em2Myam
  • increased susceptibility to parasitic infection
MGI
Irgm2em1(IMPC)J/Irgm2em1(IMPC)J [background:] C57BL/6NJ-Irgm2em1(IMPC)J/J
  • abnormal coat appearance
  • abnormal lens morphology
MGI
Irgm2em1Myam/Irgm2em1Myam [background:] C57BL/6-Irgm2em1Myam
  • increased susceptibility to parasitic infection
  • increased susceptibility to parasitic infection induced morbidity/mortality
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
58.106M58.107M58.108M58.109M58.110M58.111M58.112M58.113MENSMUST00000058704 (Irgm2)ENSMUST00000108836 (Irgm2)ENSMUST00000209079 (Irgm2)NM_019440.3 (Irgm2)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Irgm2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CfdMus musculus
protein
  • affinity chromatography technology
PMID:30550785
protein
Fndc5Mus musculus
protein
  • affinity chromatography technology
PMID:30550785
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Genetic Interactions

Irgm2 role
Irgm2 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
Fitm2Mus musculus
unspecified role
positive genetic interaction (sensu BioGRID)
  • increased cell proliferation
PMID:32968282
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