Gene

S100a8

Species
Mus musculus
Symbol
S100a8
Name
S100 calcium binding protein A8 (calgranulin A)
Synonyms
  • 60B8Ag
  • AI323541
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Acts upstream of or within astrocyte development and positive regulation of peptide secretion. Predicted to be located in cytosol; extracellular space; and intermediate filament cytoskeleton. Predicted to be part of calprotectin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including bone marrow; extraembryonic component; liver; mesometrium; and placenta. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A8 (S100 calcium binding protein A8).
MGI Description
PHENOTYPE: Homozygous disruption of this gene results in complete embryonic lethality. The exact timing of lethality varies between alleles. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11639
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensS100A810 of 10YesYes  
Rattus norvegicusS100a89 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal embryonic tissue morphology
abnormal extraembryonic tissue morphology
embryonic lethality before implantation, incomplete penetrance
embryonic lethality between somite formation and embryo turning, complete penetrance
embryonic lethality, complete penetrance
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
S100a8tm1Hogg/S100a8tm1Hogg [background:] B6.129P2-S100a8tm1Hogg
  • embryonic lethality before implantation, incomplete penetrance
  • embryonic lethality, complete penetrance
MGI
S100a8tm1Hogg/S100a8tm1Hogg [background:] involves: 129P2/OlaHsd * C57BL/6J * CD-1
  • embryonic lethality before implantation, incomplete penetrance
  • embryonic lethality, complete penetrance
MGI
S100a8tm1Hume/S100a8tm1Hume [background:] involves: 129S1/Sv * 129X1/SvJ
  • abnormal embryonic tissue morphology
  • abnormal extraembryonic tissue morphology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
90.5764M90.5765M90.5766M90.5767M90.5768M90.5769M90.5770M90.5771M90.5772M90.5773M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 4 annotations
S100a8 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Atg16l1Mus musculus
protein
  • affinity chromatography technology
PMID:30196744
protein
S100a8Mus musculus
protein
  • two hybrid
PMID:9867828
protein
S100a9Mus musculus
protein
  • two hybrid
PMID:9867828
protein
S100a9Mus musculus
protein
  • two hybrid
PMID:9867828
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Genetic Interactions

No data available