Version: 8.0.0
Date: Tue Jan 28 2025
Car1
Mus musculusMGI:88268
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Car1

Species
Mus musculus
Symbol
Car1
Name
carbonic anhydrase 1
Synonyms
  • AW555628
  • CA I
Biotype
protein coding gene
Automated Description
Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study major depressive disorder. Orthologous to human CA1 (carbonic anhydrase 1).
MGI Description
PHENOTYPE: This locus controls electrophoretic variation in red blood cells. The a allele determines a slow migrating form in C57BL/6, C3H/He and other strains; the b allele determines a fast form in IS/Cam, WB/Re, SM, M. m. castaneus and M. m. molossinus. Homozygous null mice exhibit alkalization of the hippocampal hilus, leading to reduced miniature inhibitory postsynaptic current amplitude of granule cells and induction of depression-like and anxiety behaviors. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18952
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal hippocampus CA4 region morphology
abnormal synaptic physiology
decreased miniature inhibitory postsynaptic current amplitude
enhanced long-term potentiation
increased anxiety-related response
increased depression-related behavior
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
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    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Car1tm1.1Nju/Car1tm1.1Nju [background:] involves: C57BL/6J * C57BL/6NTac
    • abnormal hippocampus CA4 region morphology
    • abnormal synaptic physiology
    		MGI
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    3 interactor genes based on 4 annotations
    Car1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Lnx1Mus musculus
    protein
    • two hybrid
    		PMID:12468544
    protein
    		Lnx1Mus musculus
    protein
    • affinity chromatography technology
    		PMID:12468544
    protein
    		Plcb1Rattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:23665500
    protein
    		Ttc23Mus musculus
    protein
    • affinity chromatography technology
    		PMID:29459677
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    Genetic Interactions

    No data available