Version: 8.0.0
Date: Tue Jan 28 2025
Gnat2
Mus musculusMGI:95779
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gnat2

Species
Mus musculus
Symbol
Gnat2
Name
G protein subunit alpha transducin 2
Synonyms
  • AW490837
  • expressed sequence AW490837
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within several processes, including detection of light stimulus; homeostasis of number of retina cells; and retina morphogenesis in camera-type eye. Is active in synapse. Is expressed in early conceptus; eye; and oocyte. Used to study achromatopsia and achromatopsia 4. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to human GNAT2 (G protein subunit alpha transducin 2).
MGI Description
PHENOTYPE: Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGNAT210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusGnat29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisgnat25 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriognat210 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterGαi3 of 9YesNo☑ ☐☐☐☐☐☑☑☐  
Caenorhabditis elegansgpa-164 of 9YesNo☑ ☐☐☐☑☐☑☑☐  
Caenorhabditis elegansgpa-44 of 9YesNo☑ ☐☐☐☑☐☑☑☐  
Saccharomyces cerevisiaeGPA17 of 9YesYes☑ ☑☑☑☑☐☐☑☑  
Saccharomyces cerevisiaeGPA23 of 9NoYes☑ ☐☐☐☐☑☑☐☐  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Gnat3135492807 of 9☑☐☑☐☑☑☑☑☑ 
Gnat1235490807 of 9☑☐☑☐☑☑☑☑☑ 
Gnai1335483697 of 9☑☐☑☐☑☑☑☑☑ 
Gnai2435583687 of 9☑☐☑☐☑☑☑☑☑ 
Gnai3535483697 of 9☑☐☑☐☑☑☑☑☑ 
Gnao1635676597 of 9☑☐☑☐☑☑☑☑☑ 
Gnaz735474567 of 9☑☐☑☐☑☑☑☑☑ 
Gnaq835566527 of 9☑☐☑☐☑☑☑☑☑ 
Gna11935566527 of 9☑☐☑☐☑☑☑☑☑ 
Gna141035167507 of 9☑☐☑☐☑☑☑☑☑ 
Gna151139855407 of 9☑☐☑☐☑☑☑☑☑ 
Gnal1236862435 of 9☑☐☑☐☐☑☑☑☐ 
Gna121335661426 of 9☑☐☑☐☐☑☑☑☑ 
Gnas1437360414 of 9☑☐☐☐☐☑☑☑☐ 
Gna131535660395 of 9☑☐☐☐☐☑☑☑☑ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cone electrophysiology
abnormal Muller cell morphology
abnormal photoreceptor outer segment morphology
abnormal retina cone bipolar cell morphology
abnormal retina cone cell morphology
abnormal retina horizontal cell morphology
abnormal retina morphology
abnormal retina photoreceptor morphology
abnormal retina rod bipolar cell morphology
abnormal retina vasculature morphology
Showing 1 - 10 of 14 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Gnat2tm1.1(cre/ERT2)Eye
    • Gnat2CreERT2
    		allele
    Gnat2tm1(KOMP)Vlcgallele
    Gnat2cpfl3-2J
    • Gnat2cpfl10
    		allele
    		YesYes
    Gnat2em1(IMPC)Bayallele
    Gnat2cpfl3
    • no cones
    		allele with one associated variant
    point mutation
    • missense variant
    		YesYes
    Gnat2m1Erica
    • Gnat2c.518AtoG
    		allele with one associated variant
    point mutation
    • missense variant
    		YesYes
    NC_000069.7:g.107995804C>Tvariant
    SNP
    • intron variant
    NC_000069.7:g.107997062C>Tvariant
    SNP
    • intron variant
    NC_000069.7:g.107998055T>Avariant
    SNP
    • intron variant
    NC_000069.7:g.108003182A>Gvariant
    SNP
    • intron variant
    Showing 1 - 10 of 308 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Gnat2cpfl3-2J/Gnat2cpfl3-2J [background:] B6.Cg-Gnat2cpfl3-2J/Boc
    • abnormal cone electrophysiology
    		MGI
    Gnat2cpfl3/Gnat2cpfl3 [background:] ALS/LtJ
    • abnormal cone electrophysiology
    • abnormal photoreceptor outer segment morphology
    		MGI
    Gnat2m1Erica/Gnat2m1Erica [background:] C.Cg-Gnat2m1Erica
    • abnormal Muller cell morphology
    • abnormal retina cone bipolar cell morphology
    		MGI
    Gnat1irdr/Gnat1irdr Gnat2cpfl3/Gnat2cpfl3 [background:] STOCK Gnat2cpfl3 Gnat1irdr/Boc
    • abnormal cone electrophysiology
    • abnormal eye electrophysiology
    		MGI
    Showing 1 - 4 of 4 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 2 annotations
    Gnat2 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		HttMus musculus
    protein
    • affinity chromatography technology
    		PMID:22794259
    protein
    		Usp48Mus musculus
    protein
    • affinity chromatography technology
    		PMID:36293380
    Showing 1 - 2 of 2 rows
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    Genetic Interactions

    No data available