Version: 8.0.0
Date: Tue Jan 28 2025
Mtm1
Rattus norvegicusRGD:1304582
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Mtm1

Species
Rattus norvegicus
Symbol
Mtm1
Name
myotubularin 1
Synonyms
  • LOC288762
  • MGC108964
Biotype
protein coding gene
Automated Description
Predicted to enable intermediate filament binding activity; phosphatase activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including dephosphorylation; muscle cell cellular homeostasis; and negative regulation of autophagosome assembly. Predicted to act upstream of or within negative regulation of intracellular signal transduction; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of skeletal muscle tissue growth. Predicted to be located in several cellular components, including I band; late endosome; and ruffle. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to human MTM1 (myotubularin 1).
RGD Description
Predicted to enable intermediate filament binding activity; phosphatase activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including dephosphorylation; muscle cell cellular homeostasis; and negative regulation of autophagosome assembly. Predicted to act upstream of or within negative regulation of intracellular signal transduction; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of skeletal muscle tissue growth. Predicted to be located in several cellular components, including I band; late endosome; and ruffle. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to human MTM1 (myotubularin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10807
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMTM110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusMtm19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalismtm19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriomtm19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogastermtm8 of 9YesNo☑ ☑☑☐☑☑☑☑☑  
Caenorhabditis elegansmtm-19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeYMR16 of 9YesNo☑ ☐☑☐☑☑☑☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Mtmr2161976617 of 9☑☐☑☐☑☑☑☑☑ 
Mtmr1260074567 of 9☑☐☑☐☑☑☑☑☑ 
Mtmr7356956377 of 9☑☐☑☐☑☑☑☑☑ 
Mtmr4467048325 of 9☑☐☑☐☐☑☑☑☐ 
Mtmr6552956377 of 9☑☐☑☐☑☑☑☑☑ 
Mtmr3665748334 of 9☑☐☐☐☐☑☑☑☐ 
Sbf1783537243 of 9☑☐☐☐☐☐☑☑☐ 
Mtmr9854153355 of 9☑☐☑☐☐☑☑☑☐ 
Sbf2987934223 of 9☑☐☐☐☐☐☑☑☐ 
Mtmr101076038233 of 9☑☐☐☐☐☐☑☑☐ 
Mtmr121165139233 of 9☑☐☐☐☐☐☑☑☐ 
Mtmr111256941243 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051341.1:g.497782C>Tvariant
    SNP
    • intron variant
    NC_051341.1:g.499459A>Cvariant
    SNP
    • intron variant
    NC_051341.1:g.496657A>Cvariant
    SNP
    • intron variant
    NC_051341.1:g.491591T>Cvariant
    SNP
    • intron variant
    NC_051341.1:g.506752C>Gvariant
    SNP
    • intron variant
    NC_051341.1:g.501647G>Avariant
    SNP
    • synonymous variant
    NC_051341.1:g.493138G>Tvariant
    SNP
    • intron variant
    NC_051341.1:g.506479T>Cvariant
    SNP
    • intron variant
    variant
    SNP
    • intron variant
    variant
    SNP
    • intron variant
    Showing 1 - 10 of 14 rows
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    View detailed Alleles/Variants information
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available