Gene

Cyp11b2

Species
Rattus norvegicus
Symbol
Cyp11b2
Name
cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms
  • ALDOS
  • aldosterone synthase
Biotype
protein coding gene
Automated Description
Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to potassium ion starvation; and steroid hormone biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1).
RGD Description
Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to potassium ion starvation; and steroid hormone biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24279
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cyp11b1150092836 of 9 
Cyp11a1249957373 of 9 
Cyp27b1353846322 of 9 
Cyp24a1450748282 of 9 
Cyp27a1545750322 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal adrenal gland morphology
decreased heart left ventricle weight
increased circulating aldosterone level
increased circulating corticosterone level
small thymus
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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106.839M106.840M106.841M106.842M106.843M106.844M106.845M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available