Version: 8.0.0Date: Tue Jan 28 2025
Gene
Mgp
- Species
- Rattus norvegicus
- Symbol
- Mgp
- Name
- matrix Gla protein
- Synonyms
- Mglap
- Biotype
- protein coding gene
- Automated Description
- Enables calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; response to calcium ion; and response to glucocorticoid. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein).
- RGD Description
- Enables calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; response to calcium ion; and response to glucocorticoid. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein); INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10109
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | MGP | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Mus musculus | Mgp | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | mgp | 5 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☑☐ |
| Danio rerio | mgp | 5 of 9 | Yes | Yes | ☑ ☑☐☐☑☐☑☑☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| calcified artery |
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Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
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Sequence Feature Viewer
- Genome location
- Chr4:169766279...169769667 - (3.39 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
1 interactor gene based on 1 annotation
Mgp molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | RNF207 | Homo sapiens | protein |
| PMID:35352799 |
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