Gene

Reln

Species
Rattus norvegicus
Symbol
Reln
Name
reelin
Synonyms
  • Reelen
  • reeler
Biotype
protein coding gene
Automated Description
Predicted to enable receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to glucocorticoid; and response to progesterone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin).
RGD Description
Predicted to enable serine-type peptidase activity and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to glucocorticoid; and response to progesterone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin); PARTICIPATES IN Reelin signaling pathway; altered Reelin signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11841
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRELN10 of 10YesYes  
Mus musculusReln9 of 9YesYes   
Xenopus tropicalisreln4 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal locomotor behavior
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
12.75M12.80M12.85M12.90M12.95M13.00M13.05M13.10M13.15M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051339.1:g.12897327C>Tvariant
SNP
  • intron variant
NC_051339.1:g.12898747G>Tvariant
SNP
  • intron variant
NC_051339.1:g.12899315A>Gvariant
SNP
  • intron variant
NC_051339.1:g.12944498G>Tvariant
SNP
  • intron variant
NC_051339.1:g.12953766G>Avariant
SNP
  • intron variant
NC_051339.1:g.12954266G>Avariant
SNP
  • intron variant
NC_051339.1:g.12876420G>Avariant
SNP
  • intron variant
NC_051339.1:g.12880353T>Gvariant
SNP
  • intron variant
NC_051339.1:g.12881980G>Avariant
SNP
  • intron variant
NC_051339.1:g.12882732G>Tvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
12.75M12.80M12.85M12.90M12.95M13.00M13.05M13.10M13.15MENSRNOT00000010521.9 (Reln)ENSRNOT00000061858.5 (Reln)NM_080394.3 (Reln)XM_006235873.4 (Reln)XM_039107060.2 (Reln)XM_039107062.2 (Reln)ENSRNOT00000114893.1 (ENSRNOG00000064707)XM_039108556.2 (Elobl5)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Reln molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
UbcRattus norvegicus
protein
  • affinity chromatography technology
PMID:22871113
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Genetic Interactions

No data available