Version: 8.1.0
Date: Fri Apr 18 2025
Pgc
Rattus norvegicusRGD:3943
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pgc

Species
Rattus norvegicus
Symbol
Pgc
Name
progastricsin
Synonyms
  • gastricsin
  • pepsinogen C
Biotype
protein coding gene
Automated Description
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production and proteolysis. Predicted to be active in extracellular space. Orthologous to human PGC (progastricsin).
RGD Description
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production and proteolysis. Predicted to be active in extracellular space. Orthologous to human PGC (progastricsin); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47966
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPGC10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusPgc9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalispgc.28 of 9YesYes☑ ☑☑☑☐☑☑☑☑  
Drosophila melanogasterBace5 of 9YesYes☑ ☐☐☑☑☑☐☑☐  
Drosophila melanogasterCG331284 of 9NoYes☑ ☐☐☑☑☐☐☑☐  
Drosophila melanogasterCG65083 of 9NoYes☑ ☐☐☑☑☐☐☐☐  
Drosophila melanogasterPgcl3 of 9NoYes☑ ☐☐☑☑☐☐☐☐  
Drosophila melanogasterCG319263 of 9NoYes☑ ☐☐☑☑☐☐☐☐  
Caenorhabditis elegansasp-12 of 9YesYes☑ ☐☐☑☐☐☐☐☐  
Saccharomyces cerevisiae S288CPEP44 of 9YesNo☑ ☐☑☐☐☑☐☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Ctse140365465 of 9☑☐☑☐☑☑☐☑☐ 
Pga3239561436 of 9☑☐☑☐☑☑☐☑☑ 
Cym339461435 of 9☑☐☑☐☑☑☐☑☐ 
Ctsd441655405 of 9☑☐☑☐☑☑☐☑☐ 
Napsa540955385 of 9☑☐☑☐☑☑☐☑☐ 
Ren640652355 of 9☑☐☑☐☑☑☐☑☐ 
Bace1746440232 of 9☑☐☐☐☐☐☐☑☐ 
Bace2835945282 of 9☑☐☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051344.1:g.13260195A>Gvariant
    SNP
    • intron variant
    NC_051344.1:g.13263103A>Gvariant
    SNP
    • intron variant
    NC_051344.1:g.13261869T>Cvariant
    SNP
    • intron variant
    NC_051344.1:g.13258902G>Avariant
    SNP
    • synonymous variant
    NC_051344.1:g.13261529C>Tvariant
    SNP
    • intron variant
    NC_051344.1:g.13264805C>Tvariant
    SNP
    • intron variant
    NC_051344.1:g.13265208T>Cvariant
    SNP
    • intron variant
    NC_051344.1:g.13260233A>Gvariant
    SNP
    • intron variant
    NC_051344.1:g.13260585G>Avariant
    SNP
    • intron variant
    NC_051344.1:g.13262744A>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 37 rows
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    View detailed Alleles/Variants information
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Transcript: Mode:

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available