Version: 8.0.0
Date: Tue Jan 28 2025
Fhl2
Rattus norvegicusRGD:61963
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fhl2

Species
Rattus norvegicus
Symbol
Fhl2
Name
four and a half LIM domains 2
Synonyms
  • FHL-2
  • four and a half LIM domains protein 2
Biotype
protein coding gene
Automated Description
Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2).
RGD Description
Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24205
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFHL210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusFhl29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisfhl29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriofhl2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriofhl2b9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterCG343252 of 9YesYes☐ ☐☑☑☐☐☐☐☐  
Drosophila melanogasterCG301782 of 9YesYes☐ ☐☑☑☐☐☐☐☐  
Caenorhabditis eleganslim-96 of 9YesYes☑ ☐☐☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Fhl5127381617 of 9☑☐☑☐☑☑☑☑☑ 
Fhl3228573536 of 9☑☐☑☐☑☐☑☑☑ 
Fhl4328066484 of 9☐☐☑☐☑☐☐☑☑ 
Fhl1423070504 of 9☐☐☑☐☑☐☐☑☑ 
Lims2528642283 of 9☐☐☐☐☑☐☐☑☑ 
Lims1628440273 of 9☐☐☐☐☑☐☐☑☑ 
Pxn721549313 of 9☐☐☐☐☑☐☐☑☑ 
Tgfb1i1823641283 of 9☐☐☐☐☑☐☐☑☑ 
Prickle3927838242 of 9☐☐☐☐☐☐☐☑☑ 
Prickle21025240272 of 9☐☐☐☐☐☐☐☑☑ 
Prickle11125337282 of 9☐☐☐☐☐☐☐☑☑ 
Lpxn1219145303 of 9☐☐☐☐☑☐☐☑☑ 
Tes1322441282 of 9☐☐☐☐☐☐☐☑☑ 
Pdlim71417947303 of 9☐☐☐☐☑☐☐☑☑ 
Pdlim51517347333 of 9☐☐☐☐☑☐☐☑☑ 
Tesl1619445312 of 9☐☐☐☐☐☐☐☑☑ 
Lmcd11722139262 of 9☐☐☐☐☐☐☐☑☑ 
Tesl11821340272 of 9☐☐☐☐☐☐☐☑☑ 
Ldb31917347342 of 9☐☐☐☐☑☐☐☑☐ 
Tesl2202 of 9☐☐☐☐☐☐☐☑☑ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051344.1:g.45406931G>Cvariant
    SNP
    • synonymous variant
    NC_051344.1:g.45407971T>Cvariant
    SNP
    • intron variant
    NC_051344.1:g.45409538A>Gvariant
    SNP
    • intron variant
    NC_051344.1:g.45411641G>Avariant
    SNP
    • intron variant
    NC_051344.1:g.45408030G>Cvariant
    SNP
    • intron variant
    NC_051344.1:g.45413222T>Cvariant
    SNP
    • intron variant
    NC_051344.1:g.45413897A>Gvariant
    SNP
    • intron variant
    NC_051344.1:g.45394707G>Avariant
    SNP
    • intron variant
    NC_051344.1:g.45406473G>Avariant
    SNP
    • intron variant
    NC_051344.1:g.45406482T>Avariant
    SNP
    • intron variant
    Showing 1 - 10 of 568 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    3 interactor genes based on 4 annotations
    Fhl2 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Gja1Rattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:26316108
    protein
    		RNF207Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:35352799
    protein
    		Sphk1Rattus norvegicus
    protein
    • fluorescence microscopy
    		PMID:16888242
    protein
    		Sphk1Rattus norvegicus
    protein
    • anti bait coimmunoprecipitation
    		PMID:16888242
    Showing 1 - 4 of 4 rows
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    Genetic Interactions

    No data available