Version: 8.0.0
Date: Tue Jan 28 2025
Sv2a
Rattus norvegicusRGD:619715
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Sv2a

Species
Rattus norvegicus
Symbol
Sv2a
Name
synaptic vesicle glycoprotein 2a
Synonyms
  • MGC105346
  • Sv2
Biotype
protein coding gene
Automated Description
Predicted to enable protein kinase binding activity. Involved in regulation of gamma-aminobutyric acid secretion. Located in dendrite; neuronal cell body; and presynaptic active zone. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A).
RGD Description
Predicted to enable protein kinase binding activity. Involved in regulation of gamma-aminobutyric acid secretion. Located in dendrite; neuronal cell body; and presynaptic active zone. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; alpha-Zearalanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23511
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSV2A10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusSv2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalissv2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriosv2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterCG31684 of 9YesYes☐ ☐☑☑☐☑☐☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Sv2c175176627 of 9☑☐☑☐☑☑☑☑☑ 
Sv2b270876636 of 9☐☐☑☐☑☑☑☑☑ 
Svop369137233 of 9☐☐☑☐☐☑☐☑☐ 
Svopl458238222 of 9☐☐☐☐☐☑☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
increased kindling response
increased susceptibility to pharmacologically induced seizures
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Sv2am1Kyo
    • Sv2aL174Q
    • Sv2am1Kyo
    		allele with one associated variant
    point mutation
    • missense variant
    		Yes
    NC_051337.1:g.183752930G>Cvariant
    NC_051337.1:g.183753259C>Gvariant
    NC_051337.1:g.183743613T>Gvariant
    SNP
    • intron variant
    NC_051337.1:g.183744619T>Gvariant
    NC_051337.1:g.183753265C>Gvariant
    SNP
    • intron variant
    NC_051337.1:g.183756053C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_051337.1:g.183744801A>Tvariant
    NC_051337.1:g.183750314G>Avariant
    SNP
    • intron variant
    NC_051337.1:g.183752082C>Gvariant
    SNP
    • intron variant
    Showing 1 - 10 of 35 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    F344-Sv2am1Kyo
    • increased kindling response
    • increased susceptibility to pharmacologically induced seizures
    		RGD
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    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    6 interactor genes based on 9 annotations
    Sv2a molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		APBB1Homo sapiens
    protein
    • anti tag coimmunoprecipitation
    		PMID:24284412
    protein
    		APBB1Homo sapiens
    protein
    • anti bait coimmunoprecipitation
    		PMID:24284412
    protein
    		APBB1Homo sapiens
    protein
    • confocal microscopy
    		PMID:24284412
    protein
    		Itm2bRattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:29476059
    protein
    		Magi2Rattus norvegicus
    protein
    • two hybrid
    		PMID:10080919
    protein
    		Rin1Rattus norvegicus
    protein
    • confocal microscopy
    		PMID:19562802
    protein
    		Syt1Rattus norvegicus
    protein
    • pull down
    		PMID:8910372
    protein
    		Syt1Rattus norvegicus
    protein
    • pull down
    		PMID:8910372
    protein
    		UbcRattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:22871113
    Showing 1 - 9 of 9 rows
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    Genetic Interactions

    No data available