Gene

Foxc2

Species
Rattus norvegicus
Symbol
Foxc2
Name
forkhead box C2
Synonyms
  • BF-3
  • brain factor 3
Biotype
protein coding gene
Automated Description
Enables DNA binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2).
RGD Description
Enables DNA binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11829
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFOXC210 of 10YesYes  
Mus musculusFoxc29 of 9YesYes   
Xenopus tropicalisfoxc28 of 9YesYes   
Drosophila melanogastercroc6 of 9YesYes   
Caenorhabditis elegansfkh-82 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Foxc1158656487 of 9 
Foxd2247943354 of 9 
Foxk2354439284 of 9 
Foxa2445744344 of 9 
Foxe1543145344 of 9 
Foxi3640446345 of 9 
Foxs1738444346 of 9 
Foxl2845940324 of 9 
Foxa1944542333 of 9 
Foxk11050437264 of 9 
Foxl11133450395 of 9 
Foxb21242142334 of 9 
Foxf11348239283 of 9 
Foxa31432450405 of 9 
Foxe31536345355 of 9 
Foxd31641844333 of 9 
Foxo11758735222 of 9 
Foxj21852036282 of 9 
Foxo31957136232 of 9 
Foxg12041142333 of 9 
Foxj32147138273 of 9 
Foxn12252437252 of 9 
Foxm12354133242 of 9 
Foxd12438839324 of 9 
Foxd42536846372 of 9 
Foxq12635648352 of 9 
Foxi12732346334 of 9 
Foxo42839544282 of 9 
Foxi22934542343 of 9 
Foxj13036543282 of 9 
Foxl33122552404 of 9 
Foxh13235437262 of 9 
Foxp13323146282 of 9 
Foxr23412449312 of 9 
Foxr1359154342 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
49.1860M49.1865M49.1870M49.1875M49.1880M49.1885M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051354.1:g.49186219T>Cvariant
SNP
  • 5 prime UTR variant
NC_051354.1:g.49188723G>Cvariant
SNP
  • 3 prime UTR variant
NC_051354.1:g.49187051C>Tvariant
SNP
  • synonymous variant
NC_051354.1:g.49187249C>Gvariant
SNP
  • synonymous variant
NC_051354.1:g.49186157C>Tvariant
SNP
  • 5 prime UTR variant
Showing 1 - 5 of 5 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
49.1860M49.1865M49.1870M49.1875M49.1880M49.1885M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available