Version: 8.0.0Date: Tue Jan 28 2025
Gene
Cul5
- Species
- Rattus norvegicus
- Symbol
- Cul5
- Name
- cullin 5
- Synonyms
- CUL-5
- cullin-5
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CUL5 (cullin 5).
- RGD Description
- Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CUL5 (cullin 5); PARTICIPATES IN neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; acetamide; acrylamide.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11932
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | CUL5 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Mus musculus | Cul5 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | cul5 | 6 of 9 | Yes | Yes | ☐ ☑☑☑☑☑☑☐☐ |
| Danio rerio | cul5a | 8 of 9 | Yes | Yes | ☑ ☑☑☑☑☐☑☑☑ |
| Danio rerio | cul5b | 5 of 9 | No | Yes | ☑ ☐☐☐☑☑☑☑☐ |
| Caenorhabditis elegans | cul-5 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| Cul4b | 1 | 908 | 44 | 26 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Cul1 | 2 | 805 | 50 | 28 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Cul4a | 3 | 853 | 46 | 26 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Cul3 | 4 | 841 | 45 | 25 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Cul2 | 5 | 784 | 48 | 27 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr8:54012963...54066751 - (53.79 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_051343.1:g.54022243G>A | variant | SNP
| |||||
| NC_051343.1:g.54023984A>C | variant | SNP
| |||||
| NC_051343.1:g.54025058A>G | variant | SNP
| |||||
| NC_051343.1:g.54026750G>T | variant | SNP
| |||||
| NC_051343.1:g.54033572C>T | variant | SNP
| |||||
| NC_051343.1:g.54043177T>C | variant | SNP
| |||||
| NC_051343.1:g.54045856G>C | variant | SNP
| |||||
| NC_051343.1:g.54050570T>A | variant | SNP
| |||||
| NC_051343.1:g.54054621A>G | variant | SNP
| |||||
| NC_051343.1:g.54045844C>T | variant | SNP
| |||||
Sequence Feature Viewer
- Genome location
- Chr8:54012963...54066751 - (53.79 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
1 interactor gene based on 1 annotation
Cul5 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | Ubc | Rattus norvegicus | protein |
| PMID:22871113 |
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