Gene

Map1lc3a

Species
Rattus norvegicus
Symbol
Map1lc3a
Name
microtubule-associated protein 1 light chain 3 alpha
Synonyms
  • autophagy-related protein LC3 A
  • autophagy-related ubiquitin-like modifier LC3 A
Biotype
protein coding gene
Automated Description
Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to oxygen-glucose deprivation; and intracellular signaling cassette. Located in autophagosome membrane and late endosome. Is active in glutamatergic synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha).
RGD Description
Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to oxygen-glucose deprivation; and intracellular signaling cassette. Located in autophagosome membrane and late endosome. Is active in glutamatergic synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); PARTICIPATES IN autophagy pathway; INTERACTS WITH 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10969
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMAP1LC3A10 of 10YesYes  
Mus musculusMap1lc3a9 of 9YesYes   
Xenopus tropicalismap1lc3a8 of 9YesYes   
Danio reriomap1lc3a8 of 9YesYes   
Caenorhabditis eleganslgg-29 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Map1lc3b112093827 of 9 
Gabarapl2211567423 of 9 
Gabarapl1311760343 of 9 
Gabarapl3411567422 of 9 
Gabarap511759323 of 9 
Gabarapl4611561372 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
143.7832M143.7834M143.7836M143.7838M143.7840M143.7842M143.7844M143.7846M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051338.1:g.143783044G>Cvariant
SNP
  • 5 prime UTR variant
NC_051338.1:g.143784670C>Avariant
SNP
  • 3 prime UTR variant
NC_051338.1:g.143783728C>Tvariant
SNP
  • synonymous variant
NC_051338.1:g.143784669G>Avariant
SNP
  • 3 prime UTR variant
NC_051338.1:g.143784561C>Tvariant
SNP
  • 3 prime UTR variant
Showing 1 - 5 of 5 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
143.7832M143.7834M143.7836M143.7838M143.7840M143.7842M143.7844M143.7846M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

6 interactor genes based on 7 annotations
Map1lc3a molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
AIM2Homo sapiens
protein
  • confocal microscopy
PMID:22286270
protein
LAMP1Homo sapiens
protein
  • fluorescence microscopy
PMID:20010805
protein
PYCARDHomo sapiens
protein
  • confocal microscopy
PMID:22286270
protein
TP53INP2Homo sapiens
protein
  • fluorescence microscopy
PMID:20010805
protein
TP53INP2Homo sapiens
protein
  • pull down
PMID:20010805
protein
Trp53inp2Mus musculus
protein
  • pull down
PMID:20010805
protein
Tuba1aRattus norvegicus
protein
  • pull down
PMID:7908909
Showing 1 - 7 of 7 rows
per page

Genetic Interactions

No data available