Gene

CDC9

Species
Saccharomyces cerevisiae
Symbol
CDC9
Name
Cell Division Cycle
Synonyms
  • MMS8
  • YDL164C
Biotype
protein coding gene
Automated Description
Enables DNA ligase (ATP) activity. Involved in DNA metabolic process and mitotic cell cycle. Located in mitochondrion and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1).
SGD Description
DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45674:SF4
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensLIG19 of 9YesYes   
Mus musculusLig19 of 9YesYes   
Rattus norvegicusLig19 of 9YesYes   
Xenopus tropicalislig18 of 9YesYes   
Danio reriolig18 of 9YesYes   
Drosophila melanogasterDNAlig19 of 9YesYes   
Caenorhabditis eleganslig-19 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal cell cycle progression in S phase
abnormal cellular morphology
abnormal chromosome/plasmid maintenance
absent X ray resistance
arrested cell cycle progression
decreased chromosome/plasmid maintenance
decreased resistance to chemicals
decreased sporulation
decreased vegetative growth
haploinsufficient
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
165.0k165.2k165.4k165.6k165.8k166.0k166.2k166.4k166.6k166.8k167.0k167.2k167.4k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
cdc9-5004allele
Yes
cdc9-1-supp2allele
cdc9-1-supp1allele
cdc9-2allele
Yes
cdc9-5006allele
Yes
cdc9-1allele
Yes
cdc9-5002allele
cdc9-Δallele
Yes
NC_001136.10:g.166634T>Cvariant
SNP
  • synonymous variant
NC_001136.10:g.166895C>Tvariant
SNP
  • synonymous variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
165.0k165.2k165.4k165.6k165.8k166.0k166.2k166.4k166.6k166.8k167.0k167.2kYDL164C_id001 (CDC9)YDL164C_id002 (CDC9)YDL165W_id001 (CDC36)YDL165W_id002 (CDC36)YDL163W_mRNA (YDL163W)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

492 interactor genes based on 596 annotations
CDC9 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
AGTRAPHomo sapiens
protein
  • two hybrid
PMID:27107014
protein
AGTRAPHomo sapiens
protein
  • two hybrid array
PMID:27107014
protein
AMF1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:11805837
protein
ARL6IP1Homo sapiens
protein
  • two hybrid
PMID:27107014
protein
ARL6IP1Homo sapiens
protein
  • two hybrid pooling approach
PMID:27107014
protein
ARL6IP1Homo sapiens
protein
  • two hybrid array
PMID:27107014
protein
ARL6IP1Homo sapiens
protein
  • validated two hybrid
PMID:27107014
RNA
BFR1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:26524240
protein
CBP1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
CDC34Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:16554755
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Genetic Interactions

CDC9 role
CDC9 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ACC1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ACS1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ACS1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:23824283
unspecified role
ADY4Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:23824283
unspecified role
AEP2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
AFG2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
AGE2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
AIM21Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:23824283
unspecified role
AIM25Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:23824283
unspecified role
AIM34Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
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