Gene

MRPL3

Species
Saccharomyces cerevisiae
Symbol
MRPL3
Name
Mitochondrial Ribosomal Protein, Large subunit
Synonyms
  • mL44
  • YmL3
Biotype
protein coding gene
Automated Description
A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44).
SGD Description
Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11207:SF32
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMRPL443 of 9YesYes   
Mus musculusMrpl443 of 9YesYes   
Rattus norvegicusMrpl444 of 9YesYes   
Xenopus tropicalismrpl444 of 9YesYes   
Danio reriomrpl444 of 9YesYes   
Drosophila melanogastermRpL444 of 9YesYes   
Caenorhabditis elegansmrpl-442 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal chemical compound accumulation
decreased cell size
decreased chemical compound accumulation
decreased chronological lifespan
decreased endocytosis
decreased rate utilization of nitrogen source
decreased rate vegetative growth
decreased stress resistance
decreased UV resistance
decreased vegetative growth
Showing 1 - 10 of 15 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensMRPL44
is implicated incombined oxidative phosphorylation deficiency 16
  • IAGP
    Showing 1 - 1 of 1 rows
    per page

    Alleles and Variants

    Genome location
    Assembly version
    R64-5-1
    Viewer Help
    322.0k322.2k322.4k322.6k322.8k323.0k323.2k
    Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    mrpl3-Δallele
    Yes
    NC_001145.3:g.322143C>Tvariant
    SNP
    • missense variant
    NC_001145.3:g.323059C>Tvariant
    SNP
    • intergenic variant
    NC_001145.3:g.323081C>Tvariant
    SNP
    • intergenic variant
    NC_001145.3:g.323229G>Avariant
    SNP
    • intergenic variant
    NC_001145.3:g.323147G>Cvariant
    SNP
    • intergenic variant
    NC_001145.3:g.322180T>Cvariant
    SNP
    • synonymous variant
    NC_001145.3:g.321892A>Cvariant
    SNP
    • missense variant
    NC_001145.3:g.321916A>Gvariant
    SNP
    • synonymous variant
    Showing 1 - 9 of 9 rows
    per page

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    R64-5-1
    Viewer Help
    322.0k322.2k322.4k322.6k322.8k323.0kYMR024W_id001 (MRPL3)YMR024W_id005 (MRPL3)

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    138 interactor genes based on 167 annotations
    MRPL3 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    ASC1Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:31062022
    protein
    ATP25Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:37968396
    RNA
    BFR1Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:26524240
    protein
    BUD31Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:15303280
    protein
    CAB2Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:37968396
    protein
    CBS1Saccharomyces cerevisiae
    protein
    • proximity labelling technology
    PMID:31883951
    protein
    CBS2Saccharomyces cerevisiae
    protein
    • proximity labelling technology
    PMID:31883951
    RNA
    CCR4Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:29158339
    protein
    CCS1Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:37968396
    protein
    COX20Saccharomyces cerevisiae
    protein
    • affinity chromatography technology
    PMID:27550809
    Showing 1 - 10 of 157 rows
    per page

    Genetic Interactions

    MRPL3 role
    MRPL3 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    ATP1Saccharomyces cerevisiae
    unspecified role
    synthetic rescue (sensu BioGRID)
    • vegetative growth
    PMID:27811238
    suppressor gene
    CNM1Saccharomyces cerevisiae
    suppressed gene
    phenotypic suppression (sensu BioGRID)
    • mitochondrial distribution, mitochondrial distribution, partial rescue
    PMID:34694322
    unspecified role
    GEM1Saccharomyces cerevisiae
    unspecified role
    synthetic growth defect (sensu BioGRID)
    • vegetative growth
    PMID:18245340
    unspecified role
    HTA1Saccharomyces cerevisiae
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • viability
    PMID:20139344
    unspecified role
    HTB1Saccharomyces cerevisiae
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • viability
    PMID:20139344
    unspecified role
    ILV1Saccharomyces cerevisiae
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • colony size
    PMID:29127264
    unspecified role
    MYO2Saccharomyces cerevisiae
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • colony size
    PMID:28615194
    unspecified role
    PMA1Saccharomyces cerevisiae
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • colony size
    PMID:27519690
    unspecified role
    SCH9Saccharomyces cerevisiae
    unspecified role
    synthetic growth defect (sensu BioGRID)
    • vegetative growth
    PMID:28604780
    unspecified role
    TOR1Saccharomyces cerevisiae
    unspecified role
    synthetic rescue (sensu BioGRID)
    • resistance to chemicals, undetermined
    PMID:11078525
    Showing 1 - 10 of 10 rows
    per page