Gene

daf-7

Species
Caenorhabditis elegans
Symbol
daf-7
Name
abnormal DAuer Formation 7
Synonyms
  • B0412.2
  • CELE_B0412.2
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to cGMP; regulation of gene expression; and response to bacterium. Located in extracellular space. Is expressed in coelomocyte; neurons; pharynx; and in male. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy and vertebral hypersegmentation and orofacial anomalies. Orthologous to several human genes including GDF11 (growth differentiation factor 11).
WB Description
daf-7 encodes a member of the transforming growth factor beta superfamily; in C. elegans, DAF-7 functions as part of a signaling pathway that interprets environmental conditions to regulate energy-balance pathways that affect dauer larval formation, adult lifespan, fat metabolism, egg laying, pathogen avoidance behavior, and feeding behavior; daf-7 reporter gene fusions are expressed in the ASI, ADE, and OLQ neurons, and daf-7 expression is induced in both ASI and ASJ chemosensory neurons in response to the pathogenic bacterial strain Pseudomonas aeruginosa PA14.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11848
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
tig-2140734222 of 8  
unc-129245731192 of 8  
dbl-1333643242 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
amplitude of sinusoidal movement variant
AWC odorant chemotaxis defective
backward locomotion variant
backward point velocity variant
bag of worms
body posture amplitude increased
body posture wavelength increased
bordering
burrowing in response to high population density increased
cadmium resistant
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
812.0k812.2k812.4k812.6k812.8k813.0k813.2k813.4k813.6k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
yj11allele
Yes
m62allele
Yes
m70allele
Yes
yj12allele
Yes
m83allele
Yes
n696allele
Yes
n708allele
m434allele
Yes
ok3125allele with one associated variant
deletion
  • splice acceptor variant
Yes
e1372allele with one associated variant
point mutation
  • splice donor variant
Yes
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
AG50WB
AMH151WB
CB1372WB
DA2202WB
DR1228WB
DR133WB
DR1799WB
DR497WB
DR62WB
GP1244WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
812.0k812.2k812.4k812.6k812.8k813.0k813.2k813.4k813.6k

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

daf-7 role
daf-7 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
bra-1Caenorhabditis elegans
unspecified role
genetic interaction
    PMID:11544101
    unspecified role
    cam-1Caenorhabditis elegans
    unspecified role
    genetic interaction
      PMID:10556063
      unspecified role
      daf-2Caenorhabditis elegans
      unspecified role
      genetic interaction
        PMID:7953519
        suppressed gene
        e1372daf-3Caenorhabditis elegans
        suppressor gene
        e1376
        genetic suppression
          PMID:8901591
          hypostatic gene
          daf-3Caenorhabditis elegans
          epistatic gene
          genetic epistasis (sensu Bateson)
            PMID:17900898
            suppressed gene
            ok3125daf-3Caenorhabditis elegans
            suppressor gene
            e1376
            genetic suppression (complete)
              PMID:25303524
              suppressed gene
              e1372daf-3Caenorhabditis elegans
              suppressor gene
              genetic suppression
                PMID:21533078
                unspecified role
                daf-3Caenorhabditis elegans
                unspecified role
                genetic interaction
                  PMID:1732156
                  unspecified role
                  daf-3Caenorhabditis elegans
                  unspecified role
                  genetic interaction
                    PMID:8375650
                    unspecified role
                    daf-3Caenorhabditis elegans
                    unspecified role
                    genetic interaction
                      PMID:7789761
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