Gene

tpa-1

Species
Caenorhabditis elegans
Symbol
tpa-1
Name
TPA (tetradecanoyl phorbol acetate) resistant 1
Synonyms
  • B0545.1
  • CELE_B0545.1
Biotype
protein coding gene
Automated Description
Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; peptidyl-serine phosphorylation; and positive regulation of antimicrobial peptide production. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Used to study Down syndrome. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta).
WB Description
tpa-1 encodes two protein kinase C isoforms, TPA-1A and TPA-1B; analysis of tpa-1 mutations indicates that at least one TPA-1 isoform plays a role in nicotine-induced adaptation and that both isoforms appear to play a role in gpa-12/G protein-mediated signaling that modulates feeding and growth.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
pkc-1168661447 of 8  
pkc-2271252397 of 8  
pkn-1374047283 of 8  
pkc-3467147314 of 8  
akt-1545155382 of 8  
akt-2638359402 of 8  
sax-1747145312 of 8  
sgk-1832960402 of 8  
R12G8.1915555432 of 8  
F48G7.101016256372 of 8  
F48G7.91114538282 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
IG339WB
IG341WB
MJ500WB
MJ563WB
PJ1043WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
92k94k96k98k100k102k104k106k108k110k

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
tpa-1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
mlk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:23072806
protein
nrx-1Caenorhabditis elegans
protein
  • proximity labelling technology
PMID:38252619
protein
sao-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36323675
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Genetic Interactions

tpa-1 role
tpa-1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
egl-19Caenorhabditis elegans
unspecified role
genetic interaction
    PMID:9697864
    unspecified role
    egl-30Caenorhabditis elegans
    unspecified role
    genetic interaction
      PMID:14704167
      suppressor gene
      k530gpa-12Caenorhabditis elegans
      suppressed gene
      genetic suppression
        PMID:22546897
        unspecified role
        gpb-2Caenorhabditis elegans
        unspecified role
        genetic interaction
          PMID:16581001
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