Gene

uev-3

Species
Caenorhabditis elegans
Symbol
uev-3
Name
Ubiquitin E2 (conjugating enzyme) variant 3
Synonyms
  • CELE_F26H9.7
  • F26H9.7
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be located in several cellular components, including axon; cilium; and dendrite. Predicted to be active in nucleus. Is expressed widely.
WB Description
uev-3 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-3 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-3 may play a role in cell cycle control or response to stress or DNA damage.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24068
Stringency:
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Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
let-70113144302 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
axon trajectory variant
cilia morphology variant
intraflagellar transport accelerated
intraflagellar transport slow
transgene subcellular localization variant
Showing 1 - 5 of 5 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.3104M9.3106M9.3108M9.3110M9.3112M9.3114M9.3116M9.3118M9.3120M9.3122M9.3124M9.3126M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

uev-3 role
uev-3 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
ju639gpa-3Caenorhabditis elegans
suppressed gene
genetic suppression
    PMID:26657059
    suppressor gene
    ju639gpa-3Caenorhabditis elegans
    suppressed gene
    genetic suppression
      PMID:26657059
      suppressor gene
      gj204gpa-3Caenorhabditis elegans
      suppressed gene
      genetic suppression
        PMID:26657059
        suppressor gene
        ju639mkk-4Caenorhabditis elegans
        suppressed gene
        genetic suppression
          PMID:20592265
          suppressor gene
          ju639mkk-4Caenorhabditis elegans
          suppressed gene
          genetic suppression
            PMID:20592265
            suppressor gene
            ju639mkk-4Caenorhabditis elegans
            suppressed gene
            genetic suppression
              PMID:20592265
              suppressor gene
              ju593rpm-1Caenorhabditis elegans
              suppressed gene
              ju44
              genetic suppression
                PMID:20592265
                suppressor gene
                ju587rpm-1Caenorhabditis elegans
                suppressed gene
                ju44
                genetic suppression
                  PMID:20592265
                  suppressor gene
                  ju638rpm-1Caenorhabditis elegans
                  suppressed gene
                  ju44
                  genetic suppression
                    PMID:20592265
                    suppressor gene
                    ju639rpm-1Caenorhabditis elegans
                    suppressed gene
                    ju44
                    genetic suppression
                      PMID:20592265
                      Showing 1 - 10 of 10 rows
                      per page