Species

Xenopus laevis

Symbol

atr.L

Name

ATR serine/threonine kinase

Synonyms

ATR serine/threonine kinase
atr.L

Biotype

gene

Automated Description

Enables protein heterodimerization activity and protein serine/threonine kinase activity. Acts upstream of or within peptidyl-serine phosphorylation. Predicted to be located in PML body. Predicted to be active in nuclear envelope and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase).

XBXL Description

Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination

https://www.xenbase.org/gene/showgene.do?method=display&geneId=1012721

Cross References

Additional Information

Literature

Orthology

Gene tree: Not Available

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	ATR	1 of 1	Yes	Yes	☑
Xenopus tropicalis	atr	1 of 1	Yes	Yes	☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

No data available

Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

No data available

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

Chr5L:117102105...117169872 - (67.77 kb)

Assembly version

XL9.2

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

Transcript: Mode:

Expression

Primary Sources

XBXL

Other Sources

None

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 10 annotations

atr.L molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	atrip.S	Xenopus laevis	protein	anti tag coimmunoprecipitation	intact:EBI-905157 imex:IM-11826-1 IntAct via IMEx	PMID:16530042
protein	CDC6	Homo sapiens	protein	pull down	biogrid:431097	PMID:20048340
protein	cdc6.L	Xenopus laevis	protein	imaging technique	biogrid:431098	PMID:20048340
protein	cdc6.L	Xenopus laevis	protein	pull down	biogrid:431095	PMID:20048340
protein	cdc6.L	Xenopus laevis	protein	affinity chromatography technology	biogrid:431096	PMID:20048340
protein	CDS1	Homo sapiens	protein	enzymatic study	biogrid:3536596	PMID:15509799
protein	chek2.L	Xenopus laevis	protein	affinity chromatography technology	biogrid:3536594	PMID:15509799
protein	chek2.L	Xenopus laevis	protein	affinity chromatography technology	biogrid:3536593	PMID:15509799
protein	mcm2.L	Xenopus laevis	protein	enzymatic study	biogrid:511081	PMID:15448142
protein	topbp1.L	Xenopus laevis	protein	affinity chromatography technology	biogrid:3218064	PMID:17446169

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Genetic Interactions

No data available