Version: 8.0.0
Date: Tue Jan 28 2025
ifih1
Danio rerioZFIN:ZDB-GENE-081104-438
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ifih1

Species
Danio rerio
Symbol
ifih1
Name
interferon induced with helicase C domain 1
Synonyms
  • mda5
  • mda5b
Biotype
protein coding gene
Automated Description
Enables protein heterodimerization activity. Acts upstream of or within regulation of DNA-templated transcription. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human IFIH1 (interferon induced with helicase C domain 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14074
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensIFIH110 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculusIfih19 of 10YesYes☐ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicusIfih19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisifih14 of 9YesYes☑ ☐☐☑☑☐☑☐☐  
Caenorhabditis elegansdrh-16 of 9YesYes☐ ☐☑☑☑☑☑☐☑  
Saccharomyces cerevisiaeYHL050C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYBL113C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYRF1-62 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYLL067C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYLL066C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYJL225C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYIL177C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Saccharomyces cerevisiaeYML133C2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
dhx58171460426 of 8☑ ☑☐☑☑☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    sa13902allele with one associated variant
    point mutation
    • stop gained
    mk29allele with one associated variant
    deletion
    • frameshift variant
    Showing 1 - 2 of 2 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Danio reriomai100Tg
    Tg(actb2:ifih1,myl7:EGFP)
    Danio reriomai101Tg
    Tg(actb2:dnifih1,myl7:EGFP)
    Danio rerioums8Tg
    Tg(actb2:ifih1_R742H,cryaa:CFP)
    Showing 1 - 3 of 3 rows
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    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    ifih1mk29/mk29; zbtb24mk22/mk22
    has condition:
    standard conditions
    • whole organism irf7 expression amount, ameliorated
    • whole organism stat1b expression amount, ameliorated
    		ZFIN
    Showing 1 - 1 of 1 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Transcript: Mode:

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available