Version: 8.1.0
Date: Fri Apr 18 2025
375 results for ISCU

Iscu

(Rattus norvegicus)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: LOC288740, similar to nitrogen fixation cluster-like, iron-sulfur cluster scaffold homolog, IscU iron-sulfur cluster scaffold homolog (E. coli), IscU iron-sulfur cluster scaffold homolog, iron-sulfur cluster assembly enzyme ISCU, iron-sulfur cluster assembly enzyme ISCU, mitochondrial, iron-sulfur cluster scaffold homolog (E. coli), RGD1309562
Source: RGD:1309562
Biotype: protein coding gene
Symbol: Iscu (Rno)
Symbol: Iscu
Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme); PARTICIPATES IN mitochondrial iron-sulfur
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Synonyms: IscU iron-sulfur cluster scaffold homolog (E. coli)...IscU iron-sulfur cluster scaffold homolog...iron-sulfur cluster assembly enzyme ISCU
Strict Orthology Symbols: ISCU

IscU

(Drosophila melanogaster)
Gene
Name: Iron-sulfur cluster assembly enzyme
Synonyms: CG9836, fIscU, dIscU, Isu1, IscU homologue, IscU homolog, iscu, Iscu
Source: FB:FBgn0037637
Biotype: protein coding gene
Symbol: IscU (Dme)
Symbol: IscU
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Synonyms: iscu...Iscu...IscU homologue...IscU homolog...iscu...Iscu
Strict Orthology Symbols: ISCU
Alleles: IscU<115> (Dme)...IscU (Dme)...IscU (Dme)

Iscu

(Mus musculus)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: AA407971, Nifun, 2310020H20Rik, RIKEN cDNA 2310020H20 gene, NifU-like N-terminal domain containing, RGD1309562, expressed sequence AA407971
Source: MGI:1913633
Biotype: protein coding gene
Symbol: Iscu (Mmu)
Symbol: Iscu
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU
Alleles: Iscu (Mmu)...Iscu (Mmu)

ISCU

(Homo sapiens)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: nifU-like N-terminal domain-containing protein, ISU2, HML, nifU-like protein, 2310020H20Rik, NIFUN, IscU iron-sulfur cluster scaffold homolog, NifU-like N-terminal domain containing, NIFU, iron-sulfur cluster scaffold homolog, MGC74517, iron-sulfur cluster assembly enzyme ISCU, iron-sulfur cluster assembly enzyme ISCU, mitochondrial, nitrogen fixation cluster-like, hnifU
Source: HGNC:29882
Biotype: protein coding gene
Symbol: ISCU (Hsa)
Symbol: ISCU
Synonyms: IscU iron-sulfur cluster scaffold homolog...iron-sulfur cluster assembly enzyme ISCU
Strict Orthology Symbols: iscu-1...iscua...iscu...IscU...Iscu

iscu

(Xenopus tropicalis)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: isu2, iron-sulfur cluster assembly enzyme, nifu, nifun, iscu
Source: Xenbase:XB-GENE-946406
Biotype: gene
Symbol: iscu (Xtr)
Symbol: iscu
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Synonyms: iscu...iscu
Strict Orthology Symbols: ISCU

iscub

(Danio rerio)
Gene
Name: iron-sulfur cluster assembly enzyme b
Synonyms: fj08f02, zgc:110331, wu:fj08f02
Source: ZFIN:ZDB-GENE-050417-332
Biotype: protein coding gene
Symbol: iscub (Dre)
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU
Symbol: iscub

iscua

(Danio rerio)
Gene
Name: iron-sulfur cluster assembly enzyme a
Synonyms: si:ch211-191d15.3, nifun, iscu
Source: ZFIN:ZDB-GENE-040724-36
Biotype: protein coding gene
Symbol: iscua (Dre)
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Synonyms: iscu...iscu
Strict Orthology Symbols: ISCU
Symbol: iscua

iscu-1

(Caenorhabditis elegans)
Gene
Name: Iron-Sulfur ClUster assembly enzyme homolog 1
Synonyms: Y45F10D.4, CELE_Y45F10D.4
Source: WB:WBGene00012885
Biotype: protein coding gene
Symbol: iscu-1 (Cel)
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU
Symbol: iscu-1

iscu.S

(Xenopus laevis)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: iscu.S, isu2, iron-sulfur cluster assembly enzyme, nifu, nifun
Source: Xenbase:XB-GENE-946412
Biotype: gene
Symbol: iscu.S (Xla)
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU
Symbol: iscu.S

iscu.L

(Xenopus laevis)
Gene
Name: iron-sulfur cluster assembly enzyme
Synonyms: isu2, iron-sulfur cluster assembly enzyme, nifu, iscu.L, nifun
Source: Xenbase:XB-GENE-17332711
Biotype: gene
Symbol: iscu.L (Xla)
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU
Symbol: iscu.L

Iscutm1(KOMP)Vlcg

(Mus musculus)
Allele/Variant
Source: MGI:3813096
Genes: Iscu (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Iscu (Mmu)
Genes: Iscu (Mmu)
Symbol: Iscutm1(KOMP)Vlcg

IscUS20E

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0301100
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Symbol: IscUS20E
Construct Expressed Component: IscU (Dme)
Construct Regulatory Region: IscU (Dme)

IscUHMC03493

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0292641
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Construct Knockdown Component: IscU (Dme)
Symbol: IscUHMC03493

IscUS20A

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0301099
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Symbol: IscUS20A
Construct Expressed Component: IscU (Dme)
Construct Regulatory Region: IscU (Dme)

IscUUAS.GFP

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0301096
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Symbol: IscUUAS.GFP
Construct Expressed Component: IscU (Dme)

IscUUAS.ORF.GW.Tag:HA

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0303600
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Symbol: IscUUAS.ORF.GW.Tag:HA
Construct Expressed Component: IscU (Dme)

IscUCR00641-TG4.0

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0342597
Genes: IscU (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Gene Synonyms: IscU homologue...IscU homolog...iscu...Iscu
Genes: IscU (Dme)
Symbol: IscUCR00641-TG4.0

IscUKK108689

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0235745
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Construct Knockdown Component: IscU (Dme)
Symbol: IscUKK108689

IscU115

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0301097
Genes: IscU (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU<115> (Dme)
Gene Synonyms: IscU homologue...IscU homolog...iscu...Iscu
Genes: IscU (Dme)
Symbol: IscU115

IscUGD14694

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0206378
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Construct Knockdown Component: IscU (Dme)
Symbol: IscUGD14694

IscUTOE.GS00395

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0325342
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Construct Knockdown Component: IscU (Dme)
Symbol: IscUTOE.GS00395

IscU+tTa

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0301098
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU<+tTa> (Dme)
Symbol: IscU+tTa
Construct Expressed Component: IscU (Dme)
Construct Regulatory Region: IscU (Dme)
Constructs: P{IscU-WT}

IscUTKO.GS03504

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0346513
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Construct Knockdown Component: IscU (Dme)
Symbol: IscUTKO.GS03504

Iscuem1Ics

(Mus musculus)
Allele/Variant
Source: MGI:7279140
Genes: Iscu (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Iscu (Mmu)
Genes: Iscu (Mmu)
Symbol: Iscuem1Ics

ISCUP1

(Homo sapiens)
Gene
Name: iron-sulfur cluster assembly enzyme pseudogene 1
Synonyms: Not Available
Source: HGNC:38021
Biotype: pseudogene
Symbol: ISCUP1 (Hsa)
Symbol: ISCUP1

Iscutm1(KOMP)Vlcg/Iscutm1(KOMP)Vlcg [background:] Not Specified

(Mus musculus)
Model
Id: MGI:7520059
Synonyms: Not Available
Symbol: Iscu/Iscu [background:] Not Specified (Mmu)
Genes: Iscu (Mmu)
Alleles: Iscu (Mmu)
Name: Iscu/Iscu [background:] Not Specified

IscUG18758

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0244307
Genes: IscU (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: IscU (Dme)
Gene Synonyms: IscU homologue...IscU homolog...iscu...Iscu
Genes: IscU (Dme)
Symbol: IscUG18758

ISU1

(Saccharomyces cerevisiae)
Gene
Name: IScU homolog
Synonyms: NUA1, YPL135W
Source: SGD:S000006056
Biotype: protein coding gene
Gene Synopsis: ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU

ISU2

(Saccharomyces cerevisiae)
Gene
Name: IscU homolog
Synonyms: NUA2, YOR226C
Source: SGD:S000005752
Biotype: protein coding gene
Gene Synopsis: ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU
Automated Gene Synopsis: Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Strict Orthology Symbols: ISCU

mitochondrial [2Fe-2S] assembly complex

Gene Ontology
Source: GO:0099128
Synonyms:
  • mitochondrial ISCU complex
  • mitochondrial iron-sulfur cluster assembly complex
Branch: cellular component
Genes: ISCU (Hsa)...Iscu (Rno)...IscU (Dme)...Iscu (Mmu)
Synonyms: mitochondrial ISCU complex
Definition: In humans it consists of ISCU, NFS1, LYRM4, NDUFAB1 and FXN.

negative regulation of iron ion import across plasma membrane

Gene Ontology
Source: GO:1904439
Synonyms:
  • down regulation of ferrous ion import into cell
  • down regulation of ferrous iron import across plasma membrane
Branch: biological process
Genes: ISCU (Hsa)...Iscu (Mmu)...Iscu (Rno)

positive regulation of mitochondrial electron transport, NADH to ubiquinone

Gene Ontology
Source: GO:1902958
Synonyms:
  • activation of complex I (NADH to ubiquinone)
  • activation of mitochondrial electron transport, NADH to ubiquinone
Branch: biological process
Genes: ISCU (Hsa)...IscU (Dme)...Iscu (Mmu)...Iscu (Rno)

[4Fe-4S] cluster assembly

Gene Ontology
Source: GO:0044572
Synonyms:
  • 4Fe-4S cluster assembly
  • [4Fe-4S] cluster biosynthetic process
Branch: biological process
Genes: ISCU (Hsa)...Iscu (Rno)...Iscu (Mmu)

[2Fe-2S] cluster assembly

Gene Ontology
Source: GO:0044571
Synonyms:
  • 2Fe-2S cluster assembly
  • [2Fe-2S] cluster biosynthetic process
Branch: biological process
Genes: ISCU (Hsa)...Iscu (Rno)...Iscu (Mmu)

positive regulation of aconitate hydratase activity

Gene Ontology
Source: GO:1904234
Synonyms:
  • activation of aconitase activity
  • activation of aconitate hydratase activity
Branch: biological process
Genes: Iscu (Mmu)

mitochondrial myopathy

Disease
Source: DOID:699
Definition: A myopathy that is characterized by mitochondrial dysfunction.
Genes: ISCU (Hsa)...iscu (Xtr)...Iscu (Mmu)...Iscu (Rno)...IscU (Dme)

ferrous iron binding

Gene Ontology
Source: GO:0008198
Synonyms: Not Available
Branch: molecular function
Genes: ISCU (Hsa)...Iscu (Mmu)...Iscu (Rno)...IscU (Dme)...iscub (Dre)

2 iron, 2 sulfur cluster binding

Gene Ontology
Source: GO:0051537
Synonyms:
  • 2 Fe 2 S cluster binding
  • 2 iron, 2 sulphur cluster binding
Branch: molecular function
Genes: ISCU (Hsa)...Iscu (Mmu)...Iscu (Rno)...IscU (Dme)...iscub (Dre)

iron-sulfur cluster assembly

Gene Ontology
Source: GO:0016226
Synonyms:
  • iron-sulfur cluster biosynthesis
  • iron-sulphur cluster assembly
Branch: biological process
Genes: ISCU (Hsa)...Iscu (Mmu)...Iscu (Rno)...IscU (Dme)...iscub (Dre)

iron-sulfur cluster assembly complex

Gene Ontology
Source: GO:1990229
Synonyms:
  • Fe-S cluster assembly complex
  • SufBCD complex
Branch: cellular component
Genes: ISCU (Hsa)...Iscu (Mmu)

clear cell renal cell carcinoma

Disease
Source: DOID:4467
Definition: A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Genes: ISCU (Hsa)...iscu.L (Xla)...Iscu (Rno)...iscu (Xtr)...Iscu (Mmu)

Hsc20

(Drosophila melanogaster)
Gene
Name: Heat shock protein cognate 20
Synonyms: l(3)72Do, heat shock protein cognate 20, lethal (3) 72Do, CG34246
Source: FB:FBgn0263606
Biotype: protein coding gene
Gene Synopsis: mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU

iron-sulfur cluster binding

Gene Ontology
Source: GO:0051536
Synonyms:
  • Fe/S binding
  • iron sulfur cluster binding
Branch: molecular function
Genes: ISCU (Hsa)...iscu-1 (Cel)...Iscu (Mmu)...IscU (Dme)...iscub (Dre)

intracellular iron ion homeostasis

Gene Ontology
Source: GO:0006879
Synonyms:
  • cellular iron ion homeostasis
  • iron homeostasis
Branch: biological process
Genes: ISCU (Hsa)...Iscu (Rno)...iscu-1 (Cel)...Iscu (Mmu)...IscU (Dme)

CG8379TOE.GS00395

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0325335
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Construct Knockdown Component: IscU (Dme)

pre-eclampsia

Disease
Source: DOID:10591
Definition: A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.
Genes: iscub (Dre)...Iscu (Rno)...iscu (Xtr)...Iscu (Mmu)...ISCU (Hsa)

Scer\GAL4IscU-CR00641-TG4.0

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0342781
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Scer\GAL4<IscU-CR00641-TG4.0>

IscS-IscU complex

Gene Ontology
Source: GO:1990330
Synonyms: Not Available
Branch: cellular component
Definition: In E. coli it consists of a central IscS dimer with the IscU protomers attached to one of the IscS units...In E. coli it consists of a central IscS dimer with the IscU protomers attached to one of the IscS units

iron ion binding

Gene Ontology
Source: GO:0005506
Synonyms:
  • iron binding
Branch: molecular function
Genes: iscub (Dre)...iscu-1 (Cel)...Iscu (Mmu)...ISCU (Hsa)...IscU (Dme)

mitochondrial matrix

Gene Ontology
Source: GO:0005759
Synonyms:
  • mitochondrial lumen
  • mitochondrial stroma
Branch: cellular component
Genes: iscub (Dre)...Iscu (Rno)...Iscu (Mmu)...ISCU (Hsa)...IscU (Dme)