Gene

moe-3

Species
Caenorhabditis elegans
Symbol
moe-3
Name
see oma 3
Synonyms
  • CELE_F32A11.6
  • F32A11.6
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be active in cytosol. Is expressed in coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1) and ZFP36L2 (ZFP36 ring finger protein like 2).
WB Description
moe-3 encodes a CCCH tandem zinc finger (TZF) protein; while loss of moe-3 activity via RNAi alone results in no obvious abnormalities, animals triply mutant for moe-3, oma-1, and oma-2 demonstrate oocyte maturation defects, indicating that these genes likely function redundantly during germline development; in situ hybridization experiments indicate that moe-3 mRNA expression is relatively weak and restricted to the distal region of the gonad; based upon its sequence similarity to other TZF proteins, such as MEX-5 and POS-1, the product of MOE-3 is predicted to function as an RNA-binding protein.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12547
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensZFP36L13 of 9YesNo   
Homo sapiensZFP36L23 of 9YesNo   
Mus musculusZfp364 of 9YesNo   
Rattus norvegicusZfp364 of 9YesNo   
Xenopus tropicaliszfp36l13 of 9YesNo   
Xenopus tropicaliszfp36l23 of 9YesNo   
Danio reriocth13 of 9YesNo   
Drosophila melanogasterTis114 of 9YesYes   
Saccharomyces cerevisiaeTIS113 of 9YesNo   
Saccharomyces cerevisiaeCTH13 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
oma-2142254436 of 8  
oma-1240652436 of 8  
ccch-1342237264 of 8  
mex-6433438243 of 8  
pos-1526040264 of 8  
mex-5629237273 of 8  
Y116A8C.19720843304 of 8  
pie-1834432222 of 8  
mex-1926342282 of 8  
F38C2.71023040234 of 8  
Y116A8C.201121839274 of 8  
dct-131219942284 of 8  
gla-31330036232 of 8  
C35D6.41419538274 of 8  
ccch-21510657384 of 8  
Y60A9.3168856404 of 8  
ccch-5178162424 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
13.1605M13.1610M13.1615M13.1620M13.1625M13.1630M13.1635M13.1640M13.1645M13.1650M13.1655M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_003280.10:g.13165718C>Tvariant
SNP
  • 5 prime UTR variant
NC_003280.10:g.13160570G>Avariant
SNP
  • 3 prime UTR variant
NC_003280.10:g.13160823A>Tvariant
NC_003280.10:g.13160972T>Gvariant
NC_003280.10:g.13162243T>Avariant
NC_003280.10:g.13164534G>Tvariant
NC_003280.10:g.13160997T>Avariant
NC_003280.10:g.13162295G>Avariant
NC_003280.10:g.13160502A>Gvariant
SNP
  • 3 prime UTR variant
NC_003280.10:g.13160587A>Tvariant
SNP
  • 3 prime UTR variant
Showing 1 - 10 of 84 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.1605M13.1610M13.1615M13.1620M13.1625M13.1630M13.1635M13.1640M13.1645M13.1650M13.1655MF32A11.6.1 (moe-3)F32A11.1.1 (F32A11.1)F32A11.1.2 (F32A11.1)F32A11.8W09H1.1a.1 (W09H1.1)W09H1.1b.1 (W09H1.1)W09H1.1c.1 (W09H1.1)W09H1.1d.1 (W09H1.1)W09H1.8 (mir-4933)W09H1.8a (mir-4933)Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

23 interactor genes based on 23 annotations
moe-3 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
C17H12.2Caenorhabditis elegans
protein
  • two hybrid
PMID:19123269
protein
ceh-21Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
egl-13Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
eya-1Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
fubl-1Caenorhabditis elegans
protein
  • two hybrid
PMID:14704431
protein
hif-1Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
hlh-11Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
ing-3Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
klf-2Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
protein
lin-48Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
Showing 1 - 10 of 23 rows
per page

Genetic Interactions

No data available