Gene

eps8

Species
Xenopus tropicalis
Symbol
eps8
Name
epidermal growth factor receptor pathway substrate 8
Synonyms
  • epidermal growth factor receptor pathway substrate 8
  • eps8
Biotype
gene
Automated Description
Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor).
XBXT Description
Epidermal growth factor receptor kinase substrate
https://www.xenbase.org/gene/showgene.do?method=display&geneId=996935
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensEPS85 of 9YesYes   
Mus musculusEps85 of 9YesYes   
Rattus norvegicusEps84 of 9YesYes   
Xenopus laeviseps8.L1 of 1YesYes           
Xenopus laeviseps8.S1 of 1YesYes           
Danio rerioeps8a5 of 9YesYes   
Drosophila melanogasterCG89074 of 9YesNo   
Drosophila melanogasteraru4 of 9YesNo   
Caenorhabditis eleganseps-83 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
eps8l2175960425 of 8  
eps8l1280356395 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensEPS8
is implicated inautosomal recessive nonsyndromic deafness 102
  • IAGP
    Drosophila melanogasteraru
    is implicated inalcohol use disorder
    • CEA
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      Transgenic Alleles

      No data available

      Models

      No data available

      Sequence Feature Viewer

      Genome location
      Assembly version
      XT9.1
      Viewer Help
      30k35k40k45k50k55k60k65kNM_001079040.2 (eps8)XT-9_1-rna34464 (Xetrov90027632m.g)

      Sequence Details

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      Expression

      Primary Sources
      Other Sources
      None
      Must provide at least one subject
      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

      Molecular Interactions

      No data available

      Genetic Interactions

      No data available