Gene

Mctp

Species
Drosophila melanogaster
Symbol
Mctp
Name
Multiple C2 domain and transmembrane region protein
Synonyms
  • CG15078
  • CG33146
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity. Involved in regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; and synaptic vesicle exocytosis. Located in endoplasmic reticulum membrane. Is active in neuromuscular junction. Is expressed in adult head; olfactory sensory organ; and organism. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1) and MCTP2 (multiple C2 and transmembrane domain containing 2).
FB Description
Multiple C2 domain and transmembrane region protein (Mctp) encodes a regulator of both neuronal synaptic plasticity and neurotransmitter secretion.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45911
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMCTP29 of 9YesYes   
Homo sapiensMCTP19 of 9YesYes   
Mus musculusMctp18 of 9YesYes   
Mus musculusMctp28 of 9YesYes   
Rattus norvegicusMctp28 of 9YesYes   
Rattus norvegicusMctp18 of 9YesYes   
Xenopus tropicalismctp25 of 9NoYes   
Xenopus tropicalismctp15 of 9YesYes   
Danio reriomctp1b8 of 10YesYes  
Danio reriomctp1a8 of 10YesYes  
Danio reriomctp2b7 of 10NoYes  
Danio reriomctp2a5 of 10NoYes  
Caenorhabditis elegansmctp-19 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Rph165832202 of 8  
Syt1251139232 of 8  
Sytα352336212 of 8  
Syt7435039232 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal neuroanatomy | third instar larval stage
abnormal neurophysiology | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage
fertile
lethal
NMJ bouton | third instar larval stage
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
MctpBG01140b
  • Mctp[BG01140]
  • Mctp[BG01140b]
allele
Yes
MctpMI02901
  • mctp[2]
  • Mctp[MI02901]
allele with one associated variant
insertion
  • coding sequence variant
Yes
Mctpe00415
  • CG33146[e00415]
  • CG33146e00415
allele with one associated variant
insertion
  • 3 prime UTR variant
Yes
MctpMI14773
  • Mctp[MI14773]
allele with one associated variant
insertion
  • intron variant
MctpOG9
  • Mctp[OG9]
  • mctp[OG9]
allele with one associated variant
insertion
  • frameshift variant
Yes
MctpMI14773-TG4.1
  • Mctp[MI14773-TG4.1]
allele with one associated variant
insertion
  • intron variant
NT_033778.4:g.18772674G>Avariant
SNP
  • synonymous variant
NT_033778.4:g.18773483C>Avariant
SNP
  • missense variant
NT_033778.4:g.18773536G>Avariant
SNP
  • synonymous variant
NT_033778.4:g.18773677G>Avariant
SNP
  • synonymous variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterMctpC2Amut.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterMctpC2Bmut.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterMctpC2Cmut.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterMctpC2D12N.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterMctpGD2076
  • UASt
Drosophila melanogasterMctpKK102643
  • UASt
Drosophila melanogasterMctpKK104930
  • UASt
Drosophila melanogasterMctpNIG.15078R
  • UASt
Drosophila melanogasterMctpU6.NIG.sgRNA
Drosophila melanogasterMctpUAS.Tag:FLAG
  • UASt
Showing 1 - 10 of 11 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
18.762M18.764M18.766M18.768M18.770M18.772M18.774MMctp-RA (Mctp)Mctp-RB (Mctp)Mctp-RD (Mctp)Mctp-RE (Mctp)Mctp-RF (Mctp)Mctp-RG (Mctp)tRNA:Leu-AAG-1-4-RA (tRNA:Leu-AAG-1-4)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Mctp molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
eyDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
Showing 1 - 1 of 1 rows
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Genetic Interactions

No data available