Gene

Cyp6a18

Species
Drosophila melanogaster
Symbol
Cyp6a18
Name
Cytochrome P450 6a18
Synonyms
  • 6a18
  • CG13977
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic/larval Malpighian tubule; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24292
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTBXAS13 of 9YesNo   
Homo sapiensCYP3A53 of 9YesNo   
Homo sapiensCYP3A433 of 9YesNo   
Homo sapiensCYP3A73 of 9YesNo   
Homo sapiensCYP3A7-CYP3A51P3 of 9YesNo   
Homo sapiensCYP3A43 of 9YesNo   
Mus musculusTbxas13 of 9YesNo   
Rattus norvegicusCyp3a625 of 9YesNo   
Rattus norvegicusCyp3a95 of 9YesNo   
Rattus norvegicusCyp3a23-3a15 of 9YesNo   
Rattus norvegicusTbxas15 of 9YesNo   
Rattus norvegicusCyp3a185 of 9YesNo   
Danio reriocyp3c15 of 10YesNo  
Danio reriotbxas15 of 10YesNo  
Caenorhabditis eleganscyp-25A26 of 9YesYes   
Caenorhabditis eleganscyp-25A16 of 9YesNo   
Caenorhabditis eleganscyp-25A46 of 9YesNo   
Caenorhabditis eleganscyp-25A36 of 9YesNo   
Saccharomyces cerevisiaeERG112 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cyp6a8150790797 of 8  
Cyp6a9450570517 of 8  
Cyp6a17550470507 of 8  
Cyp6a23650370497 of 8  
Cyp6a22750669497 of 8  
Cyp6a19850367477 of 8  
Cyp6a20950368476 of 8  
Cyp6a161051066456 of 8  
Cyp6a131150763427 of 8  
Cyp6a141251262446 of 8  
Cyp6w11351656357 of 8  
Cyp6g11451954367 of 8  
Cyp6d41552356327 of 8  
Cyp6g21652254347 of 8  
Cyp6d51748856347 of 8  
Cyp6v11854251307 of 8  
Cyp317a11950354327 of 8  
Cyp9f22051152337 of 8  
Cyp6d22151055307 of 8  
Cyp6u12250953346 of 8  
Cyp9h12352549317 of 8  
Cyp9b22451550287 of 8  
Cyp9c12551049307 of 8  
Cyp6t32650948307 of 8  
Cyp6t12750950316 of 8  
Cyp9b12849150317 of 8  
Cyp28a52953049276 of 8  
Cyp28d13052447276 of 8  
Cyp9f33151246286 of 8  
Cyp309a13252049284 of 8  
Cyp308a13352046285 of 8  
Cyp28d23451947275 of 8  
Cyp28c13551548274 of 8  
Cyp310a13652745235 of 8  
Cyp309a23751846264 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
27.4790M27.4795M27.4800M27.4805M27.4810M27.4815M27.4820M27.4825M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Cyp6a18MI15553
  • Cyp6a18[MI15553]
allele with one associated variant
insertion
  • coding sequence variant
NT_033777.3:g.27480143C>Tvariant
NT_033777.3:g.27480297A>Gvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27480334C>Avariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27482870T>Cvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27480463C>Tvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27480577T>Cvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27482828C>Gvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27481659C>Tvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.27482216T>Cvariant
SNP
  • 3 prime UTR variant
Showing 1 - 10 of 180 rows
per page

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterCyp6a18GD323
  • UASt
Drosophila melanogasterCyp6a18HMS02506
  • UAS
Drosophila melanogasterCyp6a18KK104257
  • UASt
Drosophila melanogasterCyp6a18NIG.13977R
  • UASt
Showing 1 - 4 of 4 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
27.4790M27.4795M27.4800M27.4805M27.4810M27.4815M27.4820M27.4825MCyp6a18-RA (Cyp6a18)Cyp6a18-RB (Cyp6a18)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available