Gene

Top2

Species
Drosophila melanogaster
Symbol
Top2
Name
Topoisomerase 2
Synonyms
  • CG10223
  • CHRAC
Biotype
protein coding gene
Automated Description
Enables several functions, including ATP hydrolysis activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and nucleic acid binding activity. Involved in DNA topological change; heterochromatin formation; and nuclear chromosome segregation. Located in chromosome and nucleus. Colocalizes with condensed chromosome. Is expressed in adult head and adult heart. Orthologous to several human genes including TOP2B (DNA topoisomerase II beta).
FB Description
Topoisomerase 2 (Top2) encodes an enzyme that alters the topology of DNA by creating a transient DNA double strand breakage. It is essential for removing supercoils generated via DNA replication and transcription, and decatenating replicated sister chromosomes during cell division.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10169
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTOP2B9 of 9YesYes   
Homo sapiensTOP2A8 of 9NoYes   
Mus musculusTop2b9 of 9YesYes   
Mus musculusTop2a8 of 9NoYes   
Rattus norvegicusTop2a6 of 9YesYes   
Xenopus tropicalistop2a5 of 9YesYes   
Xenopus tropicalistop2b4 of 9NoYes   
Danio reriotop2b9 of 10YesYes  
Danio reriotop2a8 of 10NoYes  
Caenorhabditis eleganstop-29 of 9YesYes   
Caenorhabditis eleganscin-44 of 9NoYes   
Saccharomyces cerevisiaeTOP29 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal developmental rate
abnormal meiotic cell cycle | spermatogenesis
abnormal neuroanatomy | somatic clone
adult mushroom body | somatic clone
chromosome
decreased body size | third instar larval stage
decreased size | adult stage | dominant
embryonic/larval salivary gland
eye
imaginal disc | third instar larval stage | heat sensitive
Showing 1 - 10 of 23 rows
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Top2 (Dme)
TOP2A (Hsa)
TOP2B (Hsa)
Top2a (Mmu)
Top2b (Mmu)
Top2a (Rno)
top2a (Xtr)
top2b (Xtr)
top2a (Dre)
top2b (Dre)
cin-4 (Cel)
top-2 (Cel)
TOP2 (Sce)
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensTOP2A
is marker forcervix uteri carcinoma in situ
  • IEP
    Homo sapiensTOP2A
    is marker for
    • severity of
    ductal carcinoma in situ
    • IEP
      Homo sapiensTOP2A
      is marker fornephroblastoma
      • IEP
        Homo sapiensTOP2A
        is marker for
        • severity of
        penile benign neoplasm
        • IEP
          Homo sapiensTOP2A
          is marker forprostate cancer
          • IEP
            Homo sapiensTOP2A
            is marker for
            • disease progression of
            urinary bladder cancer
            • IEP
              Saccharomyces cerevisiaeTOP2
              is implicated inacute myeloid leukemia
              • ISS
              Saccharomyces cerevisiaeTOP2
              is implicated inacute myeloid leukemia
              • IMP
                Saccharomyces cerevisiaeTOP2
                is implicated inB cell deficiency
                • ISS
                • IGI
                Saccharomyces cerevisiaeTOP2
                is implicated incancer
                • ISS
                • IGI
                Showing 1 - 10 of 12 rows
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                Alleles and Variants

                Genome location
                Assembly version
                R6
                Viewer Help
                19.448M19.449M19.450M19.451M19.452M19.453M
                Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
                Allele/Variant Symbol
                Allele Synonyms
                Category
                Variant
                Variant type
                Molecular consequence
                Has Disease Annotations
                Has Phenotype Annotations
                Top2unspecified
                • Top2[unspecified]
                allele
                Yes
                Top2suo1
                • suo[1]
                • suo1
                allele
                Yes
                Top2EGFP
                • Top2[EGFP]
                allele
                Top2suo2
                • suo[2]
                • suo2
                allele
                Yes
                Top2Df17
                • Top2[Df17]
                allele
                Top235-1
                • 35-1
                • Top2[35-1]
                allele with multiple associated variants
                point mutation
                • missense variant
                point mutation
                • missense variant
                point mutation
                • missense variant
                Yes
                Top217-5
                • 17-5
                • Top2[17-5]
                allele with multiple associated variants
                point mutation
                • missense variant
                point mutation
                • stop gained
                Top217-2
                • 17-2
                • Top2[17-2]
                allele with one associated variant
                point mutation
                • missense variant
                Yes
                Top217-1
                • 17-1
                • Top2[17-1]
                allele with one associated variant
                point mutation
                • missense variant
                Yes
                Top235-13
                • 35-13
                • Top2[35-13]
                allele with one associated variant
                point mutation
                • missense variant
                Yes
                Showing 1 - 10 of 86 rows
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                Transgenic Alleles

                Species
                (carrying the transgene)
                Allele symbol
                Transgenic construct
                Expressed components
                Knock-down targets
                Regulatory regions
                Has Disease Annotations
                Has Phenotype Annotations
                Drosophila melanogasterTop2+t7.1
                Drosophila melanogasterTop2GD1773
                • UASt
                Drosophila melanogasterTop2GD4570
                • UASt
                Drosophila melanogasterTop2GL00338
                • UAS
                Drosophila melanogasterTop2JF01300
                • UAS
                Drosophila melanogasterTop2KK110826
                • UASt
                Drosophila melanogasterTop2NIG.10223R
                • UASt
                Drosophila melanogasterTop2U6.NIG.sgRNA
                Drosophila melanogasterTop2UAS.cYa
                • UASt
                Drosophila melanogasterTop2UASp.Tag:HA
                • UASp
                Showing 1 - 10 of 12 rows
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                Models

                No data available

                Sequence Feature Viewer

                Genome location
                Assembly version
                R6
                Viewer Help
                19.448M19.449M19.450M19.451M19.452M19.453MTop2-RA (Top2)Top2-RB (Top2)

                Sequence Details

                Transcript: Mode:
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                Expression

                Primary Sources
                Other Sources
                all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
                Top2 (Dme)
                Top2a (Mmu)
                Top2b (Mmu)
                Top2a (Rno)
                top2a (Dre)
                top2b (Dre)
                top-2 (Cel)
                TOP2 (Sce)
                Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                Molecular Interactions

                24 interactor genes based on 43 annotations
                Top2 molecule type
                Interactor gene
                Interactor species
                Interactor molecule type
                Detection methods
                Source
                Reference
                protein
                barrDrosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:11172718
                protein
                barrDrosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:11172718
                protein
                Cenp-CDrosophila melanogaster
                protein
                • anti tag coimmunoprecipitation
                PMID:25562660
                protein
                CG3548Drosophila melanogaster
                protein
                • anti tag coimmunoprecipitation
                PMID:38944040
                protein
                Chrac-14Drosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:10856248
                protein
                IswiDrosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:9252192
                protein
                MAPK1Homo sapiens
                protein
                • enzymatic study
                PMID:10207078
                protein
                MEP-1Drosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:25776889
                protein
                Mi-2Drosophila melanogaster
                protein
                • anti bait coimmunoprecipitation
                PMID:25776889
                protein
                mleDrosophila melanogaster
                protein
                • proximity ligation assay
                PMID:25694028
                Showing 1 - 10 of 33 rows
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                Genetic Interactions

                Top2 role
                Top2 genetic perturbation
                Interactor gene
                Interactor species
                Interactor role
                Interactor genetic perturbation
                Interaction type
                Phenotype or trait
                Source
                Reference
                suppressor gene
                ctDrosophila melanogaster
                suppressed gene
                genetic suppression
                  PMID:21304601
                  enhanced gene
                  mei-41Drosophila melanogaster
                  enhancer gene
                  genetic enhancement
                    PMID:25340516
                    enhancer gene
                    mei-41Drosophila melanogaster
                    enhanced gene
                    genetic enhancement
                      PMID:25340516
                      suppressed gene
                      mofDrosophila melanogaster
                      suppressor gene
                      genetic suppression
                        PMID:25340516
                        enhanced gene
                        TctpDrosophila melanogaster
                        enhancer gene
                        genetic enhancement
                          PMID:34453033
                          enhancer gene
                          TctpDrosophila melanogaster
                          enhanced gene
                          genetic enhancement
                            PMID:34453033
                            suppressor gene
                            TctpDrosophila melanogaster
                            suppressed gene
                            genetic suppression
                              PMID:34453033
                              enhanced gene
                              tefuDrosophila melanogaster
                              enhancer gene
                              genetic enhancement
                                PMID:25340516
                                enhancer gene
                                tefuDrosophila melanogaster
                                enhanced gene
                                genetic enhancement
                                  PMID:25340516
                                  suppressor gene
                                  yDrosophila melanogaster
                                  suppressed gene
                                  genetic suppression
                                    PMID:21304601
                                    Showing 1 - 10 of 10 rows
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