Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
---|---|---|---|---|---|
Homo sapiens | TOP2B | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Homo sapiens | TOP2A | 8 of 9 | No | Yes | ☐ ☑☑☑☑☑☑☑☑ |
Mus musculus | Top2b | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Mus musculus | Top2a | 8 of 9 | No | Yes | ☐ ☑☑☑☑☑☑☑☑ |
Rattus norvegicus | Top2a | 6 of 9 | Yes | Yes | ☐ ☑☐☑☑☐☑☑☑ |
Xenopus tropicalis | top2a | 5 of 9 | Yes | Yes | ☐ ☑☐☑☑☑☑☐☐ |
Xenopus tropicalis | top2b | 4 of 9 | No | Yes | ☐ ☐☐☑☑☐☑☑☐ |
Danio rerio | top2b | 9 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☐ |
Danio rerio | top2a | 8 of 10 | No | Yes | ☐ ☑☑☑☑☑☑☑☑ ☐ |
Caenorhabditis elegans | top-2 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Caenorhabditis elegans | cin-4 | 4 of 9 | No | Yes | ☑ ☐☐☐☑☐☑☑☐ |
Saccharomyces cerevisiae | TOP2 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Phenotype Term | Annotation details | References |
---|---|---|
abnormal developmental rate | ||
abnormal meiotic cell cycle | spermatogenesis | ||
abnormal neuroanatomy | somatic clone | ||
adult mushroom body | somatic clone | ||
chromosome | ||
decreased body size | third instar larval stage | ||
decreased size | adult stage | dominant | ||
embryonic/larval salivary gland | ||
eye | ||
imaginal disc | third instar larval stage | heat sensitive |
all annotations | all disease by infectious agent | bacterial infectious disease | fungal infectious disease | parasitic infectious disease | viral infectious disease | all disease of anatomical entity | cardiovascular system disease | central nervous system disease | endocrine system disease | gastrointestinal system disease | hematopoietic system disease | immune system disease | integumentary system disease | musculoskeletal system disease | peripheral nervous system disease | reproductive system disease | respiratory system disease | sensory system disease | thoracic disease | urinary system disease | all disease of cellular proliferation | benign neoplasm | cancer | pre-malignant neoplasm | all genetic disease | chromosomal disease | monogenic disease | polygenic disease | all other disease | disease of mental health | disease of metabolism | physical disorder | syndrome | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Top2 (Dme) | |||||||||||||||||||||||||||||||||||||||
TOP2A (Hsa) | |||||||||||||||||||||||||||||||||||||||
TOP2B (Hsa) | |||||||||||||||||||||||||||||||||||||||
Top2a (Mmu) | |||||||||||||||||||||||||||||||||||||||
Top2b (Mmu) | |||||||||||||||||||||||||||||||||||||||
Top2a (Rno) | |||||||||||||||||||||||||||||||||||||||
top2a (Xtr) | |||||||||||||||||||||||||||||||||||||||
top2b (Xtr) | |||||||||||||||||||||||||||||||||||||||
top2a (Dre) | |||||||||||||||||||||||||||||||||||||||
top2b (Dre) | |||||||||||||||||||||||||||||||||||||||
cin-4 (Cel) | |||||||||||||||||||||||||||||||||||||||
top-2 (Cel) | |||||||||||||||||||||||||||||||||||||||
TOP2 (Sce) |
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
---|---|---|---|---|---|---|---|---|
Homo sapiens | TOP2A | is marker for | cervix uteri carcinoma in situ |
| ||||
Homo sapiens | TOP2A | is marker for |
| ductal carcinoma in situ |
| |||
Homo sapiens | TOP2A | is marker for | nephroblastoma |
| ||||
Homo sapiens | TOP2A | is marker for |
| penile benign neoplasm |
| |||
Homo sapiens | TOP2A | is marker for | prostate cancer |
| ||||
Homo sapiens | TOP2A | is marker for |
| urinary bladder cancer |
| |||
Saccharomyces cerevisiae | TOP2 | is implicated in | acute myeloid leukemia |
| ||||
Saccharomyces cerevisiae | TOP2 | is implicated in | acute myeloid leukemia |
| ||||
Saccharomyces cerevisiae | TOP2 | is implicated in | B cell deficiency |
| ||||
Saccharomyces cerevisiae | TOP2 | is implicated in | cancer |
|
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
Top2unspecified |
| allele | Yes | ||||
Top2suo1 |
| allele | Yes | ||||
Top2EGFP |
| allele | |||||
Top2suo2 |
| allele | Yes | ||||
Top2Df17 |
| allele | |||||
Top235-1 |
| allele with multiple associated variants | point mutation
point mutation
point mutation
| Yes | |||
Top217-5 |
| allele with multiple associated variants | point mutation
point mutation
| ||||
Top217-2 |
| allele with one associated variant | point mutation
| Yes | |||
Top217-1 |
| allele with one associated variant | point mutation
| Yes | |||
Top235-13 |
| allele with one associated variant | point mutation
| Yes |
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
Drosophila melanogaster | Top2+t7.1 | ||||||
Drosophila melanogaster | Top2GD1773 |
| |||||
Drosophila melanogaster | Top2GD4570 |
| |||||
Drosophila melanogaster | Top2GL00338 |
| |||||
Drosophila melanogaster | Top2JF01300 |
| |||||
Drosophila melanogaster | Top2KK110826 |
| |||||
Drosophila melanogaster | Top2NIG.10223R |
| |||||
Drosophila melanogaster | Top2U6.NIG.sgRNA | ||||||
Drosophila melanogaster | Top2UAS.cYa |
| |||||
Drosophila melanogaster | Top2UASp.Tag:HA |
|
|
all annotations | all anatomical structures | alimentary part of gastrointestinal system | chemosensory system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | mechanosensory system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | sensory system | vestibulo-auditory system | visual system | endoderm | ectoderm | mesoderm | mesenchyme | adipose tissue | appendage | entire extraembryonic component | imaginal precursor | pharyngeal arch | other | all stages | embryo stage | post embryonic, pre-adult | post-juvenile adult stage | all cellular components | extracellular region | plasma membrane | synapse | cell junction | cell projection | cytoplasmic vesicle | endosome | vacuole | golgi apparatus | endoplasmic reticulum | cytosol | mitochondrion | nucleus | chromosome | cytoskeleton | protein-containing complex | other locations | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Top2 (Dme) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Top2a (Mmu) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Top2b (Mmu) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Top2a (Rno) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
top2a (Dre) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
top2b (Dre) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
top-2 (Cel) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
TOP2 (Sce) |
Top2 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
---|---|---|---|---|---|---|
protein | barr | Drosophila melanogaster | protein |
| PMID:11172718 | |
protein | barr | Drosophila melanogaster | protein |
| PMID:11172718 | |
protein | Cenp-C | Drosophila melanogaster | protein |
| PMID:25562660 | |
protein | CG3548 | Drosophila melanogaster | protein |
| PMID:38944040 | |
protein | Chrac-14 | Drosophila melanogaster | protein |
| PMID:10856248 | |
protein | Iswi | Drosophila melanogaster | protein |
| PMID:9252192 | |
protein | MAPK1 | Homo sapiens | protein |
| PMID:10207078 | |
protein | MEP-1 | Drosophila melanogaster | protein |
| PMID:25776889 | |
protein | Mi-2 | Drosophila melanogaster | protein |
| PMID:25776889 | |
protein | mle | Drosophila melanogaster | protein |
| PMID:25694028 |
Top2 role | Top2 genetic perturbation | Interactor gene | Interactor species | Interactor role | Interactor genetic perturbation | Interaction type | Phenotype or trait | Source | Reference |
---|---|---|---|---|---|---|---|---|---|
suppressor gene | ct | Drosophila melanogaster | suppressed gene | genetic suppression | PMID:21304601 | ||||
enhanced gene | mei-41 | Drosophila melanogaster | enhancer gene | genetic enhancement | PMID:25340516 | ||||
enhancer gene | mei-41 | Drosophila melanogaster | enhanced gene | genetic enhancement | PMID:25340516 | ||||
suppressed gene | mof | Drosophila melanogaster | suppressor gene | genetic suppression | PMID:25340516 | ||||
enhanced gene | Tctp | Drosophila melanogaster | enhancer gene | genetic enhancement | PMID:34453033 | ||||
enhancer gene | Tctp | Drosophila melanogaster | enhanced gene | genetic enhancement | PMID:34453033 | ||||
suppressor gene | Tctp | Drosophila melanogaster | suppressed gene | genetic suppression | PMID:34453033 | ||||
enhanced gene | tefu | Drosophila melanogaster | enhancer gene | genetic enhancement | PMID:25340516 | ||||
enhancer gene | tefu | Drosophila melanogaster | enhanced gene | genetic enhancement | PMID:25340516 | ||||
suppressor gene | y | Drosophila melanogaster | suppressed gene | genetic suppression | PMID:21304601 |