Gene

SGK1

Species
Homo sapiens
Symbol
SGK1
Name
serum/glucocorticoid regulated kinase 1
Synonyms
  • serine/threonine protein kinase SGK
  • serine/threonine-protein kinase Sgk1
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine/tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and neuron projection morphogenesis. Predicted to act upstream of or within several processes, including cellular response to aldosterone; cellular response to insulin stimulus; and positive regulation of sodium ion transport. Located in cytosol and nuclear speck. Implicated in hypertension. Biomarker of granulosa cell tumor; mucinous cystadenocarcinoma; and serous cystadenocarcinoma.
RGD Description
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24351
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
134.18M134.20M134.22M134.24M134.26M134.28M134.30M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions