Enables protein serine/threonine/tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and neuron projection morphogenesis. Predicted to act upstream of or within several processes, including cellular response to aldosterone; cellular response to insulin stimulus; and positive regulation of sodium ion transport. Located in cytosol and nuclear speck. Implicated in hypertension. Biomarker of granulosa cell tumor; mucinous cystadenocarcinoma; and serous cystadenocarcinoma.
RGD Description
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]