Version: 8.1.0Date: Fri Apr 18 2025
Gene
SGK1
- Species
- Homo sapiens
- Symbol
- SGK1
- Name
- serum/glucocorticoid regulated kinase 1
- Synonyms
- serine/threonine protein kinase SGK
- serine/threonine-protein kinase Sgk1
- Biotype
- protein coding gene
- Automated Description
- Enables protein serine/threonine/tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and neuron projection morphogenesis. Predicted to act upstream of or within several processes, including cellular response to aldosterone; cellular response to insulin stimulus; and positive regulation of sodium ion transport. Located in cytosol and nuclear speck. Implicated in hypertension. Biomarker of granulosa cell tumor; mucinous cystadenocarcinoma; and serous cystadenocarcinoma.
- RGD Description
- This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24351
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Mus musculus | Sgk1 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Sgk1 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Xenopus laevis | sgk1.S | 1 of 1 | Yes | Yes | ☑ |
| Xenopus laevis | sgk1.L | 1 of 1 | Yes | Yes | ☑ |
| Xenopus tropicalis | sgk1 | 8 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☐☑☑ |
| Danio rerio | sgk1 | 9 of 10 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ ☑ |
| Caenorhabditis elegans | sgk-1 | 8 of 9 | Yes | No | ☐ ☑☑☑☑☑☑☑☑ |
| Saccharomyces cerevisiae S288C | YPK1 | 4 of 9 | Yes | Yes | ☐ ☐☑☐☐☑☑☐☑ |
| Saccharomyces cerevisiae S288C | YPK2 | 3 of 9 | No | Yes | ☐ ☐☑☐☐☑☐☐☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| SGK3 | 1 | 434 | 78 | 66 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| C8orf44-SGK3 | 1 | 434 | 78 | 66 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| SGK2 | 2 | 368 | 86 | 71 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| AKT1 | 3 | 524 | 54 | 38 | 3 of 8 | ☐ ☐☐☐☑☑☑☐ |
| PRKCE | 4 | 610 | 48 | 32 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PRKCA | 5 | 578 | 49 | 33 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PRKCH | 6 | 571 | 50 | 33 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| AKT3 | 7 | 434 | 59 | 45 | 3 of 8 | ☐ ☐☐☐☑☑☑☐ |
| PRKCI | 8 | 551 | 51 | 34 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PRKCD | 9 | 587 | 48 | 32 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| AKT2 | 10 | 450 | 56 | 42 | 3 of 8 | ☐ ☐☐☐☑☑☑☐ |
| PRKCG | 11 | 543 | 50 | 34 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PRKCB | 12 | 529 | 51 | 34 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PKN1 | 13 | 503 | 52 | 34 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| LATS2 | 14 | 559 | 45 | 28 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| LATS1 | 15 | 612 | 43 | 26 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| PRKCQ | 16 | 471 | 51 | 38 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PKN3 | 17 | 478 | 51 | 36 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PRKCZ | 18 | 447 | 51 | 34 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| PKN2 | 19 | 431 | 52 | 36 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| STK38 | 20 | 477 | 48 | 28 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| DMPK | 21 | 415 | 48 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| STK38L | 22 | 519 | 42 | 25 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| MAST3 | 23 | 408 | 50 | 32 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| MAST4 | 24 | 415 | 50 | 30 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| MAST2 | 25 | 391 | 51 | 31 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| MAST1 | 26 | 356 | 52 | 34 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| PDPK1 | 27 | 316 | 57 | 39 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| STK32B | 28 | 336 | 51 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| STK32A | 29 | 337 | 51 | 31 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| STK32C | 30 | 308 | 52 | 34 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| MASTL | 31 | 276 | 49 | 33 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
Phenotypes
- Primary Sources
- Other Sources
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr6:134169248...134318112 - (148.86 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_000006.12:g.134175584C>T | variant | SNP
| |||||
| NC_000006.12:g.134170390C>G | variant | SNP
| |||||
| NC_000006.12:g.134261969G>C | variant | SNP
| |||||
| NC_000006.12:g.134170402C>T | variant | SNP
| |||||
| NC_000006.12:g.134174596A>G | variant | SNP
| |||||
| NC_000006.12:g.134207381T>C | variant | SNP
| |||||
| NC_000006.12:g.134173085G>A | variant | SNP
| |||||
| NC_000006.12:g.134173523G>A | variant | SNP
| |||||
| NC_000006.12:g.134170333C>T | variant | SNP
| |||||
| NC_000006.12:g.134170319G>A | variant | SNP
| |||||
Sequence Feature Viewer
- Genome location
- Chr6:134169248...134318112 - (148.86 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
SGK1 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection method | Source | Reference |
|---|---|---|---|---|---|---|
protein | AKT1S1 | Homo sapiens | protein | affinity chromatography technology | PMID:18570873 | |
protein | ARL5B | Homo sapiens | protein | affinity chromatography technology | PMID:28514442 | |
protein | ARL5B | Homo sapiens | protein | affinity chromatography technology | PMID:26186194 | |
protein | ASPG | Homo sapiens | protein | affinity chromatography technology | PMID:21063096 | |
protein | ASPG | Homo sapiens | protein | two hybrid | PMID:21063096 | |
protein | ASPG | Homo sapiens | protein | affinity chromatography technology | PMID:21063096 | |
protein | ASPG | Homo sapiens | protein | pull down | PMID:21063096 | |
protein | CAMKK2 | Homo sapiens | protein | affinity chromatography technology | PMID:12628440 | |
protein | CARHSP1 | Homo sapiens | protein | pull down | PMID:15910284 | |
protein | CD40 | Homo sapiens | protein | affinity chromatography technology | PMID:17353931 |
Genetic Interactions
SGK1 role | SGK1 genetic perturbation | Interactor gene | Interactor species | Interactor role | Interactor genetic perturbation | Interaction type | Phenotype or trait | Source | Reference |
|---|---|---|---|---|---|---|---|---|---|
unspecified role | AKT3 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) | PMID:34857952 | ||||
unspecified role | RPS6KB1 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) | PMID:34857952 | ||||
suppressor gene | YPK1 | Saccharomyces cerevisiae | suppressed gene | dosage rescue (sensu BioGRID) |
| PMID:20516150 |
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