Version: 8.0.0
Date: Tue Jan 28 2025
TIA1
Homo sapiensHGNC:11802
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

TIA1

Species
Homo sapiens
Symbol
TIA1
Name
TIA1 cytotoxic granule associated RNA binding protein
Synonyms
  • ALS26
  • cytotoxic granule associated RNA binding protein TIA1
Biotype
protein coding gene
Automated Description
Enables RNA binding activity. Involved in protein localization to cytoplasmic stress granule; regulation of alternative mRNA splicing, via spliceosome; and stress granule assembly. Located in cytosol; nucleoplasm; and ribonucleoprotein granule. Implicated in amyotrophic lateral sclerosis type 26.
RGD Description
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10352
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusTia110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusTia110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Xenopus laevistia1.S1 of 1YesYes          ☑ 
Xenopus laevistia1.L1 of 1YesYes          ☑ 
Xenopus tropicalistia19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriotia110 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Danio reriotia1l3 of 10NoYes☑ ☐☐☐☑☐☐☑☐ ☐
Drosophila melanogasterRox88 of 9YesYes☑ ☑☑☐☑☑☑☑☑  
Drosophila melanogasterCG343545 of 9NoYes☑ ☑☐☐☑☐☑☑☐  
Drosophila melanogastertrv4 of 9NoYes☐ ☑☐☐☑☐☑☑☐  
Caenorhabditis eleganstiar-28 of 9YesYes☑ ☑☑☑☑☑☐☑☑  
Caenorhabditis eleganstiar-17 of 9NoYes☐ ☑☑☑☑☑☐☑☑  
Saccharomyces cerevisiaePUB15 of 9YesYes☐ ☑☐☑☑☑☐☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
TIAL1141180737 of 8☑ ☑☐☑☑☑☑☑ 
RBM47239840242 of 8☑ ☐☐☐☐☐☑☐ 
RBM4B341836212 of 8☑ ☐☐☐☐☐☑☐ 
RBM46437839222 of 8☑ ☐☐☐☐☐☑☐ 
RBM39534643232 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPD637937242 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1D740635202 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1E740635202 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1B840435212 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1A1840435212 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1J940635202 of 8☑ ☐☐☐☐☐☑☐ 
RBMY1F940635202 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPA2B11038635232 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPDL1137736222 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPAB1233038252 of 8☑ ☐☐☐☐☐☑☐ 
MSI21331440242 of 8☑ ☐☐☐☐☐☑☐ 
DAZAP11434435232 of 8☑ ☐☐☐☐☐☑☐ 
A1CF1531242222 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPA1L21631838222 of 8☑ ☐☐☐☐☐☑☐ 
MSI11729841232 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPA31830538232 of 8☑ ☐☐☐☐☐☑☐ 
RBM41929939232 of 8☑ ☐☐☐☐☐☑☐ 
RBMX2032935202 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPA02126642232 of 8☑ ☐☐☐☐☐☑☐ 
RBM192224545252 of 8☑ ☐☐☐☐☐☑☐ 
RBM14-RBM42328537232 of 8☑ ☐☐☐☐☐☑☐ 
TRNAU1AP2421346282 of 8☑ ☐☐☐☐☐☑☐ 
CIRBP2527036232 of 8☑ ☐☐☐☐☐☑☐ 
RBM232619349282 of 8☑ ☐☐☐☐☐☑☐ 
DND12726535202 of 8☑ ☐☐☐☐☐☑☐ 
NCL2818944302 of 8☑ ☐☐☐☐☐☑☐ 
RBMXL2299257362 of 8☑ ☐☐☐☐☐☑☐ 
RBMXL1309356332 of 8☑ ☐☐☐☐☐☑☐ 
RBM3318160402 of 8☑ ☐☐☐☐☐☑☐ 
HNRNPA1L3322 of 8☑ ☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Adult onset
Amyotrophic lateral sclerosis
Aphasia
Autosomal dominant inheritance
Autosomal recessive inheritance
Bulbar palsy
Cardiomyopathy
Clumsiness
Distal amyotrophy
Distal muscle weakness
Showing 1 - 10 of 30 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000002.12:g.70224652G>Avariant
    SNP
    • intron variant
    NC_000002.12:g.70216486C>Gvariant
    SNP
    • missense variant
    NC_000002.12:g.70227753G>Avariant
    SNP
    • missense variant
    NC_000002.12:g.70236171C>Tvariant
    SNP
    • missense variant
    NC_000002.12:g.70216908G>Avariant
    SNP
    • synonymous variant
    NC_000002.12:g.70224606A>Gvariant
    SNP
    • missense variant
    NC_000002.12:g.70229067C>Tvariant
    SNP
    • missense variant
    NC_000002.12:g.70229313G>Cvariant
    SNP
    • synonymous variant
    NC_000002.12:g.70224594T>Gvariant
    SNP
    • missense variant
    NC_000002.12:g.70229086T>Avariant
    SNP
    • missense variant
    Showing 1 - 10 of 241 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    125 interactor genes based on 156 annotations
    TIA1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		AK1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:26496610
    protein
    		ALG13Homo sapiens
    protein
    • proximity labelling technology
    		PMID:29395067
    protein
    		ANXA7Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:25461769
    protein
    		ANXA7Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:25461769
    protein
    		ARIH2Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:31253590
    protein
    		BCAR1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33001583
    protein
    		BCORHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:26687479
    protein
    		BMI1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:24457600
    protein
    		C9orf72Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:37317656
    protein
    		CAND1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:21145461
    Showing 1 - 10 of 155 rows
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    Genetic Interactions

    TIA1 role
    TIA1 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    		EGFRHomo sapiens
    unspecified role
    positive genetic interaction (sensu BioGRID)
    • Growth abnormality
    • viability
    		PMID:31741433
    Showing 1 - 1 of 1 rows
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