Species

Homo sapiens

Symbol

RBM14-RBM4

Name

RBM14-RBM4 readthrough

Synonyms

COAZ
FLJ78260

Biotype

protein coding gene

Automated Description

Enables nuclear receptor coactivator activity. Involved in several processes, including centriole assembly; negative regulation of centriole replication; and positive regulation of macromolecule biosynthetic process. Located in cytoplasm and nuclear speck. Part of transcription regulator complex.

RGD Description

This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR48025

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculus	Rbm14	9 of 10	Yes	No	☑☐☑☑☑☑☑☑☑☑
Rattus norvegicus	Rbm14	9 of 10	Yes	No	☑☐☑☑☑☑☑☑☑☑
Danio rerio	rbm14a	3 of 10	Yes	No	☑ ☑☑☐☐☐☐☐☐ ☐
Danio rerio	rbm14b	3 of 10	Yes	No	☑ ☑☑☐☐☐☐☐☐ ☐

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
RBM4	1	365	82	75	4 of 8	☑ ☐☐☐☑☑☑☐
RBM4B	2	366	75	65	4 of 8	☑ ☐☐☐☑☑☑☐
RBM47	3	522	31	21	2 of 8	☑ ☐☐☐☐☐☑☐
RBMY1D	4	400	33	21	3 of 8	☑ ☐☐☐☐☑☑☐
RBMY1J	5	414	31	21	3 of 8	☑ ☐☐☐☐☑☑☐
RBMXL1	6	407	33	21	2 of 8	☑ ☐☐☐☐☐☑☐
MSI1	7	367	35	24	2 of 8	☑ ☐☐☐☐☐☑☐
RBMY1B	8	400	33	21	2 of 8	☑ ☐☐☐☐☐☑☐
RBMY1E	8	400	33	21	2 of 8	☑ ☐☐☐☐☐☑☐
RBMX	9	406	32	21	2 of 8	☑ ☐☐☐☐☐☑☐
A1CF	10	373	33	20	2 of 8	☑ ☐☐☐☐☐☑☐
RBM39	11	323	37	22	2 of 8	☑ ☐☐☐☐☐☑☐
RBM46	12	307	36	22	2 of 8	☑ ☐☐☐☐☐☑☐
RBMXL2	13	370	27	20	2 of 8	☑ ☐☐☐☐☐☑☐
TIA1	14	285	37	23	2 of 8	☑ ☐☐☐☐☐☑☐
HNRNPAB	15	243	40	23	2 of 8	☑ ☐☐☐☐☐☑☐
HNRNPDL	16	252	36	21	2 of 8	☑ ☐☐☐☐☐☑☐
HNRNPD	17	239	38	21	2 of 8	☑ ☐☐☐☐☐☑☐
DAZAP1	18	231	36	24	2 of 8	☑ ☐☐☐☐☐☑☐
TIAL1	19	228	38	22	2 of 8	☑ ☐☐☐☐☐☑☐
NCL	20	258	34	18	2 of 8	☑ ☐☐☐☐☐☑☐
RBM19	21	160	42	28	3 of 8	☑ ☐☐☐☐☑☑☐
RBM23	22	213	38	23	2 of 8	☑ ☐☐☐☐☐☑☐
CIRBP	23	200	38	25	2 of 8	☑ ☐☐☐☐☐☑☐
SRSF10	24	160	44	27	2 of 8	☐ ☐☐☐☐☑☑☐
SRSF9	25	200	34	21	2 of 8	☐ ☐☐☐☐☑☑☐
RBMXL3	26	172	35	26	2 of 8	☑ ☐☐☐☐☐☑☐
SRSF7	27	160	33	22	2 of 8	☐ ☐☐☐☐☑☑☐
SRSF1	28	140	36	20	2 of 8	☐ ☐☐☐☐☑☑☐
SRSF12	29	123	36	24	2 of 8	☐ ☐☐☐☐☑☑☐
SRSF3	30	88	45	33	2 of 8	☐ ☐☐☐☐☑☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

None

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

No data available

Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

Chr11:66616626...66646469 + (29.84 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Category	Variant
NC_000011.10:g.66624676C>T	variant	rs1382335867 SNP missense variant
NC_000011.10:g.66624499C>A	variant	NC_000011.10:g.66624499C>A SNP missense variant
NC_000011.10:g.66624529G>A	variant	rs1329491753 SNP missense variant
NC_000011.10:g.66625630G>A	variant	rs1052652681 SNP missense variant
NC_000011.10:g.66624772C>T	variant	rs780935422 SNP missense variant
NC_000011.10:g.66624934C>T	variant	rs766037809 SNP missense variant
NC_000011.10:g.66624769C>G	variant	NC_000011.10:g.66624769C>G SNP missense variant
NC_000011.10:g.66625143G>A	variant	rs980591621 SNP missense variant
NC_000011.10:g.66624473T>C	variant	NC_000011.10:g.66624473T>C SNP synonymous variant
NC_000011.10:g.66624826C>G	variant	rs141633741 SNP missense variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

Chr11:66616626...66646469 + (29.84 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

Transcript: Mode:

Expression

Primary Sources

None

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

103 interactor genes based on 141 annotations

RBM14-RBM4 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	AARSD1	Homo sapiens	protein	affinity chromatography technology	biogrid:2244786	PMID:28514442
protein	AARSD1	Homo sapiens	protein	affinity chromatography technology	biogrid:3111810	PMID:33961781
protein	ANKRD39	Homo sapiens	protein	affinity chromatography technology	biogrid:3068165	PMID:33961781
protein	AP1G2	Homo sapiens	protein	affinity chromatography technology	biogrid:2232456	PMID:28514442
protein	AP1G2	Homo sapiens	protein	affinity chromatography technology	biogrid:3103231	PMID:33961781
protein	APBB3	Homo sapiens	protein	affinity chromatography technology	biogrid:2244062	PMID:28514442
protein	APBB3	Homo sapiens	protein	affinity chromatography technology	biogrid:3111017	PMID:33961781
protein	BCL2L14	Homo sapiens	protein	affinity chromatography technology	biogrid:3176600	PMID:33961781
protein	BORCS8	Homo sapiens	protein	affinity chromatography technology	biogrid:3136372	PMID:33961781
protein	C3orf49	Homo sapiens	protein	affinity chromatography technology	biogrid:3041541	PMID:33961781

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Genetic Interactions

RBM14-RBM4 role	RBM14-RBM4 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
unspecified role		GBF1	Homo sapiens	unspecified role		negative genetic interaction (sensu BioGRID)	Growth abnormality, viability	biogrid:3540914	PMID:36305789
unspecified role		KRAS	Homo sapiens	unspecified role		synthetic lethality (sensu BioGRID)		biogrid:2619523	PMID:28700943

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