Gene

MLST8

Species
Homo sapiens
Symbol
MLST8
Name
MTOR associated protein, LST8 homolog
Synonyms
  • G protein beta subunit like
  • G protein beta subunit-like
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activator activity and protein-macromolecule adaptor activity. Involved in TOR signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex.
RGD Description
Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Nov 2024]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19842
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusMlst810 of 10YesYes  
Rattus norvegicusMlst810 of 10YesYes  
Xenopus laevismlst8.L1 of 1YesYes           
Xenopus tropicalismlst89 of 9YesYes   
Danio reriomlst810 of 10YesYes  
Drosophila melanogasterLst89 of 9YesYes   
Caenorhabditis elegansmlst-89 of 9YesYes   
Saccharomyces cerevisiaeLST89 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
2.2045M2.2050M2.2055M2.2060M2.2065M2.2070M2.2075M2.2080M2.2085M2.2090M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000016.10:g.2206098C>Tvariant
SNP
  • missense variant
NC_000016.10:g.2207281A>Cvariant
SNP
  • missense variant
NC_000016.10:g.2207325A>Gvariant
SNP
  • missense variant
NC_000016.10:g.2206383C>Tvariant
SNP
  • missense variant
NC_000016.10:g.2208211G>Avariant
SNP
  • missense variant
NC_000016.10:g.2209405C>Tvariant
SNP
  • 3 prime UTR variant
NC_000016.10:g.2209442G>Avariant
SNP
  • missense variant
NC_000016.10:g.2207086C>Avariant
SNP
  • missense variant
NC_000016.10:g.2207282G>Cvariant
SNP
  • missense variant
NC_000016.10:g.2208235C>Tvariant
SNP
  • missense variant
Showing 1 - 10 of 17 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
2.2045M2.2050M2.2055M2.2060M2.2065M2.2070M2.2075M2.2080M2.2085M2.2090MENST00000301724.14 (MLST8)ENST00000382450.8 (MLST8)ENST00000397124.5 (MLST8)ENST00000561651.5 (MLST8)ENST00000562043.1 (MLST8)ENST00000562239.1 (MLST8)ENST00000562352.5 (MLST8)ENST00000562392.1 (MLST8)ENST00000562479.5 (MLST8)ENST00000562844.5 (MLST8)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

114 interactor genes based on 194 annotations
MLST8 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
A2MHomo sapiens
protein
  • two hybrid
PMID:21163940
protein
ACAT2Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
ACAT2Homo sapiens
protein
  • affinity chromatography technology
PMID:28514442
protein
ANKRD49Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
RNA
APEX1Homo sapiens
protein
  • affinity chromatography technology
PMID:28986522
protein
APPL2Homo sapiens
protein
  • two hybrid
PMID:25814554
protein
ARGFXHomo sapiens
protein
  • proximity labelling technology
PMID:38297188
protein
ATXN1Homo sapiens
protein
  • two hybrid
PMID:23275563
protein
BAG3Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
BAG5Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
Showing 1 - 10 of 192 rows
per page

Genetic Interactions

MLST8 role
MLST8 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
EGFRHomo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • Growth abnormality, viability
PMID:34373451
unspecified role
FASNHomo sapiens
unspecified role
positive genetic interaction (sensu BioGRID)
  • Growth abnormality
  • viability
PMID:32694731
Showing 1 - 2 of 2 rows
per page