Species

Homo sapiens

Symbol

IGF2BP1

Name

insulin like growth factor 2 mRNA binding protein 1

Synonyms

coding region determinant-binding protein
CRD-BP

Biotype

protein coding gene

Automated Description

Enables N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and translation regulator activity. Involved in post-transcriptional regulation of gene expression. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Part of CRD-mediated mRNA stability complex and ribonucleoprotein complex.

RGD Description

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR10288

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculus	Igf2bp1	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Rattus norvegicus	Igf2bp1	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Danio rerio	igf2bp1	9 of 10	Yes	Yes	☐ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogaster	Imp	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Caenorhabditis elegans	imph-1	8 of 9	Yes	Yes	☑ ☑☑☐☑☑☑☑☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
IGF2BP3	1	591	84	74	7 of 8	☑ ☑☐☑☑☑☑☑
IGF2BP2	2	609	78	65	7 of 8	☑ ☑☐☑☑☑☑☑
KHSRP	3	499	38	24	3 of 8	☑ ☐☐☐☐☑☑☐
NOVA1	4	522	35	22	3 of 8	☑ ☐☐☐☐☑☑☐
NOVA2	5	487	36	24	3 of 8	☑ ☐☐☐☐☑☑☐
HNRNPK	6	501	36	18	4 of 8	☑ ☐☐☐☐☑☑☑
FUBP3	7	437	41	24	3 of 8	☑ ☐☐☐☐☑☑☐
FUBP1	8	443	41	23	3 of 8	☑ ☐☐☐☐☑☑☐
PCBP4	9	412	34	22	3 of 8	☑ ☐☐☐☐☑☑☐
PCBP1	10	365	41	23	3 of 8	☑ ☐☐☐☐☑☑☐
PCBP2	11	400	40	20	2 of 8	☐ ☐☐☐☐☑☑☐
PCBP3	12	230	43	27	3 of 8	☑ ☐☐☐☐☑☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

None

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

No data available

Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Alleles and Variants

Genome location

Chr17:48996558...49056145 + (59.59 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Category	Variant
NC_000017.11:g.49040021C>T	variant	rs758955317 SNP missense variant
NC_000017.11:g.49042318G>A	variant	NC_000017.11:g.49042318G>A SNP missense variant
NC_000017.11:g.49038273G>A	variant	rs267604935 SNP synonymous variant
NC_000017.11:g.49038421C>T	variant	rs754194926 SNP missense variant
NC_000017.11:g.49039981C>T	variant	rs74548664 SNP synonymous variant
NC_000017.11:g.49043504C>A	variant	rs748846744 SNP missense variant
NC_000017.11:g.49043976G>A	variant	rs778356223 SNP missense variant
NC_000017.11:g.49049433C>T	variant	rs149888111 SNP missense variant
NC_000017.11:g.49055457T>C	variant	rs6504593 SNP 3 prime UTR variant
NC_000017.11:g.49042376G>A	variant	rs746264929 SNP missense variant

Showing 1 - 10 of 30 rows

per page

1
2
3
>

View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Regulatory regions
Drosophila melanogaster	Hsap\IGF2BP1^UAS.GFP	P{UAS-hIGF2BP1.GFP}	IGF2BP1 (Hsa) GFP	UASt
Drosophila melanogaster	Hsap\IGF2BP1^UAS.Tag:HA	PBac{UAS-hIGF2BP1.HA}	IGF2BP1 (Hsa) Tag:HA	UASt
Drosophila melanogaster	Hsap\IGF2BP1^UAS.cFa	P{UAS-hIGF2BP1.F}	IGF2BP1 (Hsa)	UASt

Showing 1 - 3 of 3 rows

per page

1

Models

No data available

Sequence Feature Viewer

Genome location

Chr17:48996558...49056145 + (59.59 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

Transcript: Mode:

Expression

Primary Sources

None

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

518 interactor genes based on 648 annotations

IGF2BP1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	AATF	Homo sapiens	protein	affinity chromatography technology	biogrid:3473169	PMID:31363146
protein	ACE2	Homo sapiens	protein	affinity chromatography technology	biogrid:3487923	PMID:36057605
protein	ACE2	Homo sapiens	protein	affinity chromatography technology	biogrid:3644605	PMID:38245532
protein	ACE2	Homo sapiens	protein	affinity chromatography technology	biogrid:3644687	PMID:38245532
protein	ACTC1	Homo sapiens	protein	affinity chromatography technology	biogrid:2575407	PMID:30890647
protein	AGO1	Homo sapiens	protein	proximity labelling technology	biogrid:2818026	PMID:29395067
protein	AGO1	Homo sapiens	protein	affinity chromatography technology	biogrid:3217737	PMID:17932509
protein	AGO2	Homo sapiens	protein	proximity labelling technology	biogrid:2818743	PMID:29395067
protein	AGO2	Homo sapiens	protein	affinity chromatography technology	biogrid:3217691	PMID:17932509
protein	AGO4	Homo sapiens	protein	affinity chromatography technology	biogrid:566912	PMID:19167051

Showing 1 - 10 of 607 rows

per page

1
2
3
4
5
>
>>

Genetic Interactions

IGF2BP1 role	Interactor gene	Interactor species	Interactor role	Interaction type	Phenotype or trait	Source	Reference
unspecified role	ARFGAP2	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539191	PMID:28319085
unspecified role	ARIH2	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539319	PMID:28319085
unspecified role	B3GNT2	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539219	PMID:28319085
unspecified role	BMI1	Homo sapiens	unspecified role	negative genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2538707	PMID:28319085
unspecified role	CAND1	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539183	PMID:28319085
unspecified role	CUL5	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539476	PMID:28319085
unspecified role	DCAF7	Homo sapiens	unspecified role	negative genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539034	PMID:28319085
unspecified role	EP300	Homo sapiens	unspecified role	positive genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539342	PMID:28319085
unspecified role	HDAC8	Homo sapiens	unspecified role	negative genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2538938	PMID:28319085
unspecified role	HMGCR	Homo sapiens	unspecified role	negative genetic interaction (sensu BioGRID)	Growth abnormality	biogrid:2539097	PMID:28319085

Showing 1 - 10 of 41 rows

per page

1
2
3
4
5
>