Gene

VWC2L

Species
Homo sapiens
Symbol
VWC2L
Name
von Willebrand factor C domain containing 2 like
Synonyms
  • brorin-like
  • von Willebrand factor C domain containing protein 2 like
Biotype
protein coding gene
Automated Description
Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space.
RGD Description
Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46252
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusVwc2l10 of 10YesYes  
Rattus norvegicusVwc2l10 of 10YesYes  
Xenopus laevisvwc2l.S1 of 1YesYes           
Xenopus laevisvwc2l.L1 of 1YesYes           
Xenopus laevisvwc2l.2.S1 of 1YesNo           
Xenopus laevisvwc2l.2.L1 of 1YesNo           
Xenopus tropicalisvwc2l2 of 9YesYes   
Danio reriovwc2l10 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
VWC2119971563 of 8  
BMPER228834252 of 8  
KCP317243352 of 8  
VWCE417345312 of 8  
MUC19517641302 of 8  
CRIM1614945312 of 8  
CHRDL1714046322 of 8  
CHRDL2814140272 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
214.42M214.44M214.46M214.48M214.50M214.52M214.54M214.56M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000002.12:g.214414553G>Avariant
SNP
  • synonymous variant
NC_000002.12:g.214436720T>Cvariant
SNP
  • missense variant
NC_000002.12:g.214575687C>Tvariant
SNP
  • missense variant
NC_000002.12:g.214414252C>Tvariant
SNP
  • missense variant
NC_000002.12:g.214414312A>Gvariant
SNP
  • missense variant
NC_000002.12:g.214414575G>Avariant
SNP
  • missense variant
NC_000002.12:g.214575813C>Gvariant
SNP
  • missense variant
NC_000002.12:g.214414390G>Tvariant
SNP
  • missense variant
NC_000002.12:g.214414347G>Tvariant
SNP
  • missense variant
NC_000002.12:g.214414216C>Tvariant
SNP
  • missense variant
Showing 1 - 10 of 12 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
214.42M214.44M214.46M214.48M214.50M214.52M214.54M214.56MENST00000312504.10 (VWC2L)ENST00000427124.1 (VWC2L)ENST00000477752.1 (VWC2L)NM_001080500.4 (VWC2L)NM_001345929.2 (VWC2L)NR_159945.1 (VWC2L)ENST00000416430.1 (VWC2L-IT1)NR_047698.1 (VWC2L-IT1)

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

38 interactor genes based on 39 annotations
VWC2L molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
C17orf50Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
C22orf39Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
CD36Homo sapiens
protein
  • pull down
PMID:36178190
protein
CEMP1Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
CHEK1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
CRCT1Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
CTC1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
CXCL5Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
CYSRT1Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
DEFB112Homo sapiens
protein
  • two hybrid
PMID:32296183
Showing 1 - 10 of 39 rows
per page

Genetic Interactions

No data available