Gene

LBP

Species
Homo sapiens
Symbol
LBP
Name
lipopolysaccharide binding protein
Synonyms
  • BPI fold containing family D, member 2
  • BPIFD2
Biotype
protein coding gene
Automated Description
Enables several functions, including coreceptor activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including positive regulation of innate immune response; regulation of cytokine production; and response to bacterium. Acts upstream of or within cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; and positive regulation of tumor necrosis factor production. Located in cell surface and extracellular space.
RGD Description
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10504
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusLbp10 of 10YesYes  
Rattus norvegicusLbp10 of 10YesYes  
Xenopus tropicalisbpi.44 of 9YesYes   
Danio reriobpifcl4 of 10YesYes  
Caenorhabditis elegansF01G10.106 of 9YesYes   
Caenorhabditis elegansC55C3.15 of 9NoYes   
Caenorhabditis elegansF10D11.64 of 9NoYes   
Caenorhabditis elegansC05C9.13 of 9NoYes   
Caenorhabditis elegansT19C3.53 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
BPI146965456 of 8  
BPIFC248946255 of 8  
PLTP348644244 of 8  
BPIFB2449443242 of 8  
CETP549339243 of 8  
BPIFB6651637222 of 8  
BPIFB3750038222 of 8  
BPIFB4853336202 of 8  
BPIFB1935740212 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
38.350M38.355M38.360M38.365M38.370M38.375M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

19 interactor genes based on 22 annotations
LBP molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
APOA1Homo sapiens
protein
  • affinity chromatography technology
PMID:8663389
protein
BAG6Homo sapiens
protein
  • two hybrid
PMID:21988832
protein
BDNFHomo sapiens
protein
  • two hybrid array
PMID:32814053
protein
BDNFHomo sapiens
protein
  • two hybrid pooling approach
PMID:32814053
protein
BDNFHomo sapiens
protein
  • validated two hybrid
PMID:32814053
protein
BST1Homo sapiens
protein
  • two hybrid
PMID:21988832
protein
C4BPAHomo sapiens
protein
  • two hybrid
PMID:21988832
protein
CBFA2T2Homo sapiens
protein
  • two hybrid
PMID:21988832
protein
CD14Homo sapiens
protein
  • pull down
PMID:12417309
protein
CD14Homo sapiens
protein
  • biochemical
PMID:7583357
Showing 1 - 10 of 21 rows
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Genetic Interactions

LBP role
LBP genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
CSKHomo sapiens
unspecified role
synthetic lethality (sensu BioGRID)
  • Growth abnormality
  • viability
PMID:29987050
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