Version: 8.0.0
Date: Tue Jan 28 2025
Gapvd1
Mus musculusMGI:1913941
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gapvd1

Species
Mus musculus
Symbol
Gapvd1
Name
GTPase activating protein and VPS9 domains 1
Synonyms
  • 2010005B09Rik
  • 4432404J10Rik
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol. Is expressed in several structures, including gonad; inner ear; nervous system; nucleus pulposus; and thymus primordium. Orthologous to human GAPVD1 (GTPase activating protein and VPS9 domains 1).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23101
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGAPVD110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusGapvd19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisgapvd15 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriogapvd110 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterGapvd18 of 9YesYes☑ ☑☑☑☑☑☑☐☑  
Caenorhabditis elegansrme-68 of 9YesYes☑ ☑☑☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Rin31103632213 of 9☑☐☐☐☐☐☑☑☐ 
Rin2299032202 of 9☐☐☐☐☐☐☑☑☐ 
Rin1383631203 of 9☑☐☐☐☐☐☑☑☐ 
Vps9d1481732183 of 9☑☐☐☐☐☐☑☑☐ 
Rinl546633223 of 9☑☐☐☐☐☐☑☑☐ 
Rabgef1624147263 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal eye morphology
abnormal heart morphology
abnormal kidney morphology
abnormal liver morphology
abnormal lymph node morphology
abnormal skin morphology
abnormal spleen morphology
anophthalmia
embryonic growth retardation
embryonic lethality prior to organogenesis
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    No mapped variant information available
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Gapvd1em1(IMPC)Mbpallele
    		Yes
    NC_000068.8:g.34564951C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_000068.8:g.34564977C>Avariant
    SNP
    • 3 prime UTR variant
    NC_000068.8:g.34568568G>Tvariant
    SNP
    • synonymous variant
    NC_000068.8:g.34568028T>Cvariant
    SNP
    • 3 prime UTR variant
    NC_000068.8:g.34568324G>Avariant
    SNP
    • intron variant
    NC_000068.8:g.34568374T>Gvariant
    SNP
    • intron variant
    NC_000068.8:g.34572312G>Avariant
    SNP
    • intron variant
    NC_000068.8:g.34572381G>Avariant
    SNP
    • intron variant
    NC_000068.8:g.34572636A>Gvariant
    SNP
    • intron variant
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Gapvd1em1(IMPC)Mbp/Gapvd1+ [background:] C57BL/6N-Gapvd1em1(IMPC)Mbp/Ucd
    • abnormal eye morphology
    • abnormal heart morphology
    		MGI
    Gapvd1em1(IMPC)Mbp/Gapvd1em1(IMPC)Mbp [background:] C57BL/6N-Gapvd1em1(IMPC)Mbp/Ucd
    • embryonic lethality prior to organogenesis
    • prenatal lethality prior to heart atrial septation
    		MGI
    Showing 1 - 2 of 2 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    3 interactor genes based on 3 annotations
    Gapvd1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    RNA
    		Atg5Mus musculus
    protein
    • affinity chromatography technology
    		PMID:35449600
    protein
    		Atxn1Mus musculus
    protein
    • proximity labelling technology
    		PMID:30457570
    protein
    		EedMus musculus
    protein
    • affinity chromatography technology
    		PMID:24457600
    Showing 1 - 3 of 3 rows
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    Genetic Interactions

    No data available