Gene

Sestd1

Species
Mus musculus
Symbol
Sestd1
Name
SEC14 and spectrin domains 1
Synonyms
  • 1500031J16Rik
  • MGC:51459
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Predicted to be involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be located in intermediate filament cytoskeleton. Predicted to be part of calcium channel complex. Is expressed in cranial ganglion and dorsal root ganglion. Orthologous to human SESTD1 (SEC14 and spectrin domain containing 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality, short and curly tail, absent genital tubercle, blind-end colon, hydronephrosis, absent bladder and more rounded posterior contour. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46607
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Kalrn175246262 of 9 
Trio273346262 of 9 
Mcf2l373440232 of 9 
Mcf2477036222 of 9 
D630003M21Rik558338242 of 9 
Plekhg4664232202 of 9 
Vav1754135202 of 9 
Spata13856232192 of 9 
Arhgef25951634192 of 9 
Vav31032235202 of 9 
Vav21127341192 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal colon morphology
abnormal embryo development
abnormal genital tubercle morphology
abnormal neural tube morphology
absent anus
absent urinary bladder
curly tail
hydronephrosis
neonatal lethality, complete penetrance
short tail
Showing 1 - 10 of 11 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Dact1tm1.1Bnrc/Dact1+ Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc [background:] involves: 129S6/SvEvTac * C57BL/6NCr
  • abnormal genital tubercle morphology
  • short tail
MGI
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Sestd1tm1.1Bnrc/Sestd1+ [background:] involves: 129S6/SvEvTac * C57BL/6NCr
  • abnormal genital tubercle morphology
  • short tail
MGI
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc [background:] involves: 129S6/SvEvTac * C57BL/6NCr
  • abnormal genital tubercle morphology
  • short tail
MGI
Sestd1tm1.1Bnrc/Sestd1+ Vangl2Lp/Vangl2+ [background:] involves: 129S6/SvEvTac * A * C57BL/6NCr
  • curly tail
MGI
Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc [background:] involves: 129S6/SvEvTac * C57BL/6NCr
  • abnormal colon morphology
  • abnormal embryo development
MGI
Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc Vangl2Lp/Vangl2+ [background:] involves: 129S6/SvEvTac * A * C57BL/6NCr
  • abnormal reproductive system development
  • abnormal urinary system development
MGI
Showing 1 - 6 of 6 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
77.02M77.03M77.04M77.05M77.06M77.07M77.08M77.09M77.10M77.11M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

10 interactor genes based on 11 annotations
Sestd1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Asap1Mus musculus
protein
  • two hybrid
PMID:18685082
protein
CadpsMus musculus
protein
  • two hybrid
PMID:15102471
protein
CFL1Homo sapiens
protein
  • affinity chromatography technology
PMID:26496610
protein
ChukMus musculus
protein
  • two hybrid
PMID:15102471
protein
ChukMus musculus
protein
  • two hybrid
PMID:15102471
protein
Dlg4Mus musculus
protein
  • affinity chromatography technology
PMID:36604605
protein
KalrnMus musculus
protein
  • affinity chromatography technology
PMID:28706196
protein
LPPHomo sapiens
protein
  • affinity chromatography technology
PMID:26496610
protein
PRDX5Homo sapiens
protein
  • affinity chromatography technology
PMID:26496610
protein
Sting1Mus musculus
protein
  • proximity labelling technology
PMID:32554809
Showing 1 - 10 of 11 rows
per page

Genetic Interactions