Version: 8.0.0Date: Tue Jan 28 2025
Gene
Pi4ka
- Species
- Mus musculus
- Symbol
- Pi4ka
- Name
- phosphatidylinositol 4-kinase alpha
- Synonyms
- phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
- PI4K-alpha
- Biotype
- protein coding gene
- Automated Description
- Enables 1-phosphatidylinositol 4-kinase activity. Involved in myelination in peripheral nervous system and phosphatidylinositol phosphate biosynthetic process. Acts upstream of or within Schwann cell migration and actin cytoskeleton organization. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha).
- MGI Description
- PHENOTYPE: Mice homozygous for a targeted knock-out or knock-in conditionally activated exhibit premature death associated with degeneration of mucosal cells in the stomach and intestines. Mice homozygous for a knock-out allele exhibit early embryonic lethality. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10048
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | PI4KA | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Pi4ka | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | pi4ka | 4 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☐☐ |
| Danio rerio | pi4kaa | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Danio rerio | pi4kab | 4 of 10 | No | Yes | ☑ ☐☐☐☑☐☐☑☐ ☑ |
| Drosophila melanogaster | Pi4KIIIα | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Caenorhabditis elegans | Y75B8A.24 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Saccharomyces cerevisiae | STT4 | 7 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☐☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| Pik3c2a | 1 | 1529 | 34 | 20 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3cg | 2 | 1419 | 34 | 20 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3c2g | 3 | 1394 | 34 | 20 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3c2b | 4 | 1315 | 35 | 21 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3ca | 5 | 1159 | 37 | 22 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3cd | 6 | 1214 | 35 | 20 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3cb | 7 | 1022 | 37 | 21 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pik3c3 | 8 | 987 | 35 | 21 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Pi4kb | 9 | 663 | 45 | 28 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Phenotypes
- Primary Sources
- Other Sources
Phenotype Term | Annotation details | References |
|---|---|---|
| abnormal cecum morphology | ||
| abnormal coat appearance | ||
| abnormal digestion | ||
| abnormal digestive system morphology | ||
| abnormal duodenum morphology | ||
| abnormal gastric parietal cell morphology | ||
| abnormal intestine morphology | ||
| abnormal large intestine crypts of Lieberkuhn morphology | ||
| abnormal large intestine morphology | ||
| abnormal small intestinal villus morphology |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
No mapped variant information availableAllele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| Pi4katm2.1Arte |
| allele | Yes | ||||
| Pi4kaGt(OST391157)Lex | allele | ||||||
| Pi4katm1.1Tbal |
| allele | |||||
| Pi4katm1.1Arte |
| allele | Yes | ||||
| Pi4katm1.2Pdc | allele | Yes | |||||
| Pi4katm1.1Pdc |
| allele | |||||
| Pi4katm1a(EUCOMM)Wtsi | allele | ||||||
| Pi4kaem31Gpt |
| allele | |||||
| Pi4kaem1Gpt |
| allele | |||||
| Pi4kaGt(RRO073)Byg | allele | ||||||
Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Mmus\Pi4kaUAS.Tag:M(mCd8a) |
|
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Models
Sequence Feature Viewer
- Genome location
- Chr16:17098215...17224178 - (125.96 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
16 interactor genes based on 20 annotations
Pi4ka molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | Actb | Mus musculus | protein |
| PMID:32325033 | |
RNA | Atg5 | Mus musculus | protein |
| PMID:35449600 | |
protein | Braf | Mus musculus | protein |
| PMID:27034005 | |
protein | CALM1 | Homo sapiens | protein |
| PMID:16512683 | |
protein | Cyfip1 | Mus musculus | protein |
| PMID:28671696 | |
protein | Efr3b | Mus musculus | protein |
| PMID:23229899 | |
protein | Efr3b | Mus musculus | protein |
| PMID:23229899 | |
protein | Efr3b | Mus musculus | protein |
| PMID:23229899 | |
protein | Hdac4 | Mus musculus | protein |
| PMID:31040226 | |
protein | Kctd13 | Mus musculus | protein |
| PMID:37142655 |