Gene

Pi4ka

Species
Mus musculus
Symbol
Pi4ka
Name
phosphatidylinositol 4-kinase alpha
Synonyms
  • phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
  • PI4K-alpha
Biotype
protein coding gene
Automated Description
Enables 1-phosphatidylinositol 4-kinase activity. Involved in myelination in peripheral nervous system and phosphatidylinositol phosphate biosynthetic process. Acts upstream of or within Schwann cell migration and actin cytoskeleton organization. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha).
MGI Description
PHENOTYPE: Mice homozygous for a targeted knock-out or knock-in conditionally activated exhibit premature death associated with degeneration of mucosal cells in the stomach and intestines. Mice homozygous for a knock-out allele exhibit early embryonic lethality. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
17.10M17.12M17.14M17.16M17.18M17.20M17.22M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions