Version: 8.0.0
Date: Tue Jan 28 2025
Aldob
Rattus norvegicusRGD:2090
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Aldob

Species
Rattus norvegicus
Symbol
Aldob
Name
aldolase, fructose-bisphosphate B
Synonyms
  • Aldo2
  • aldolase B
Biotype
protein coding gene
Automated Description
Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to insulin stimulus; response to fructose; and response to interleukin-6. Located in perinuclear region of cytoplasm; rough endoplasmic reticulum membrane; and smooth endoplasmic reticulum membrane. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B).
RGD Description
Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to insulin stimulus; response to fructose; and response to interleukin-6. Located in perinuclear region of cytoplasm; rough endoplasmic reticulum membrane; and smooth endoplasmic reticulum membrane. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B); PARTICIPATES IN forkhead class A signaling pathway; fructose and mannose metabolic pathway; fructosuria pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2,2-tetramine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11627
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensALDOB10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusAldob9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisaldob5 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio rerioaldob9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterAld18 of 9YesNo☑ ☑☑☐☑☑☑☑☑  
Drosophila melanogasterAld26 of 9NoYes☑ ☑☐☐☑☑☑☑☐  
Caenorhabditis elegansaldo-17 of 9YesNo☐ ☑☑☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Aldoc136483717 of 9☑☐☑☐☑☑☑☑☑ 
Aldoa236484717 of 9☑☐☑☐☑☑☑☑☑ 
Aldoart2336482687 of 9☑☐☑☐☑☑☑☑☑ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051340.1:g.63901423C>Avariant
    SNP
    • intron variant
    NC_051340.1:g.63889918C>Gvariant
    SNP
    • intron variant
    NC_051340.1:g.63900209G>Avariant
    SNP
    • intron variant
    NC_051340.1:g.63894605G>Avariant
    SNP
    • intron variant
    NC_051340.1:g.63890754A>Gvariant
    SNP
    • missense variant
    NC_051340.1:g.63900334T>Cvariant
    SNP
    • intron variant
    NC_051340.1:g.63896143A>Tvariant
    SNP
    • intron variant
    NC_051340.1:g.63898049C>Tvariant
    SNP
    • intron variant
    NC_051340.1:g.63901633C>Gvariant
    SNP
    • intron variant
    NC_051340.1:g.63896142G>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 41 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    1 interactor gene based on 1 annotation
    Aldob molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Wipf1Rattus norvegicus
    protein
    • anti bait coimmunoprecipitation
    		PMID:16990791
    Showing 1 - 1 of 1 rows
    per page

    Genetic Interactions

    No data available