Version: 8.1.0Date: Fri Apr 18 2025
Gene
Pola1
- Species
- Rattus norvegicus
- Symbol
- Pola1
- Name
- DNA polymerase alpha 1, catalytic subunit
- Synonyms
- DNA polymerase alpha catalytic subunit
- DNA polymerase alpha catalytic subunit p180
- Biotype
- protein coding gene
- Automated Description
- Enables DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit).
- RGD Description
- Enables DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; aphidicolin.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR45861
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | POLA1 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Mus musculus | Pola1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | pola1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Drosophila melanogaster | PolA1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Caenorhabditis elegans | pola-1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Saccharomyces cerevisiae S288C | POL1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available
Alleles and Variants
- Genome location
- ChrX:58034617...58348612 - (314.00 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_051356.1:g.58129824T>C | variant | SNP
| |||||
| NC_051356.1:g.58166789T>A | variant | SNP
| |||||
| NC_051356.1:g.58166790C>A | variant | SNP
| |||||
| NC_051356.1:g.58173472A>G | variant | SNP
| |||||
| NC_051356.1:g.58265091T>G | variant | SNP
| |||||
| NC_051356.1:g.58046335A>C | variant | SNP
| |||||
| NC_051356.1:g.58046372T>A | variant | SNP
| |||||
| NC_051356.1:g.58046381T>C | variant | SNP
| |||||
| NC_051356.1:g.58046393A>T | variant | SNP
| |||||
| NC_051356.1:g.58046545A>G | variant | SNP
| |||||
Sequence Feature Viewer
- Genome location
- ChrX:58034617...58348612 - (314.00 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction