Version: 8.0.0Date: Tue Jan 28 2025
Gene
RRP7
- Species
- Saccharomyces cerevisiae
- Symbol
- RRP7
- Name
- Ribosomal RNA Processing
- Synonyms
- YCL031C
- Biotype
- protein coding gene
- Automated Description
- Enables rRNA binding activity. Involved in rRNA processing and ribosomal small subunit assembly. Located in nucleolus. Part of CURI complex and UTP-C complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A).
- SGD Description
- Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13191:SF0
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | RRP7A | 5 of 9 | Yes | Yes | ☑ ☑☐☐☑☐☑☑☐ |
| Homo sapiens | RRP7BP | 3 of 9 | No | Yes | ☑ ☐☐☐☑☐☐☑☐ |
| Mus musculus | Rrp7a | 4 of 9 | Yes | Yes | ☑ ☑☐☐☑☐☑☐☐ |
| Rattus norvegicus | Rrp7a | 6 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☐☐ |
| Xenopus tropicalis | rrp7a | 7 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☐ |
| Danio rerio | rrp7a | 4 of 9 | Yes | Yes | ☑ ☑☐☐☑☐☑☐☐ |
| Drosophila melanogaster | CG9107 | 6 of 9 | Yes | Yes | ☑ ☑☐☐☑☑☑☑☐ |
| Caenorhabditis elegans | ZC434.4 | 5 of 9 | Yes | Yes | ☑ ☑☐☐☑☐☑☑☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| decreased competitive fitness | ||
| decreased rate growth in exponential phase | ||
| decreased resistance to chemicals | ||
| haploinsufficient | ||
| increased resistance to chemicals | ||
| inviable |
Showing 1 - 6 of 6 rows
per page
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
Showing 0 - 0 of 0 rows
per page
Alleles and Variants
- Genome location
- ChrIII:64675...65568 - (0.89 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| rrp7-5001 | allele | Yes | |||||
| rrp7-5007 | allele | Yes | |||||
| rrp7-Δ | allele | Yes | |||||
| NC_001135.5:g.65123G>A | variant | SNP
| |||||
| NC_001135.5:g.65119T>C | variant | SNP
| |||||
| NC_001135.5:g.65087G>C | variant | SNP
| |||||
Showing 1 - 6 of 6 rows
per page
Sequence Feature Viewer
- Genome location
- ChrIII:64675...65568 - (0.89 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
188 interactor genes based on 252 annotations
RRP7 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | ASC1 | Saccharomyces cerevisiae | protein |
| PMID:31062022 | |
protein | BBC1 | Saccharomyces cerevisiae | protein |
| PMID:19841731 | |
protein | BEM1 | Saccharomyces cerevisiae | protein |
| PMID:19841731 | |
protein | BFR2 | Saccharomyces cerevisiae | protein |
| PMID:21724601 | |
protein | BFR2 | Saccharomyces cerevisiae | protein |
| PMID:37968396 | |
protein | BMH1 | Saccharomyces cerevisiae | protein |
| PMID:35240051 | |
protein | BMS1 | Saccharomyces cerevisiae | protein |
| PMID:37968396 | |
protein | BOI1 | Saccharomyces cerevisiae | protein |
| PMID:19841731 | |
protein | BUD14 | Saccharomyces cerevisiae | protein |
| PMID:19841731 | |
protein | BUD21 | Saccharomyces cerevisiae | protein |
| PMID:37968396 |
Genetic Interactions
RRP7 role | RRP7 genetic perturbation | Interactor gene | Interactor species | Interactor role | Interactor genetic perturbation | Interaction type | Phenotype or trait | Source | Reference |
|---|---|---|---|---|---|---|---|---|---|
unspecified role | BUD21 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:27708008 | |||
unspecified role | CBT1 | Saccharomyces cerevisiae | unspecified role | positive genetic interaction (sensu BioGRID) |
| PMID:19061648 | |||
unspecified role | CKB2 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:19061648 | |||
unspecified role | CLA4 | Saccharomyces cerevisiae | unspecified role | dosage growth defect (sensu BioGRID) |
| PMID:22282571 | |||
unspecified role | CST9 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:27708008 | |||
unspecified role | CTK1 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:19061648 | |||
unspecified role | DBR1 | Saccharomyces cerevisiae | unspecified role | positive genetic interaction (sensu BioGRID) |
| PMID:19061648 | |||
unspecified role | DOM34 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:27708008 | |||
unspecified role | ELP3 | Saccharomyces cerevisiae | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:19061648 | |||
unspecified role | EMP46 | Saccharomyces cerevisiae | unspecified role | positive genetic interaction (sensu BioGRID) |
| PMID:27708008 |