Gene

PHA2

Species
Saccharomyces cerevisiae
Symbol
PHA2
Name
PHenylAlanine requiring
Synonyms
  • YNL316C
Biotype
protein coding gene
Automated Description
Enables prephenate dehydratase activity. Involved in L-phenylalanine biosynthetic process. Located in cytoplasm.
SGD Description
Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21022:SF19
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
absent utilization of nitrogen source
auxotrophy
decreased chronological lifespan
decreased competitive fitness
decreased resistance to chemicals
decreased silencing
haploinsufficient
increased resistance to chemicals
viable
Showing 1 - 9 of 9 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
42.1k42.2k42.3k42.4k42.5k42.6k42.7k42.8k42.9k43.0k43.1k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
pha2-Δ
  • pha2-delta
allele
Yes
NC_001146.8:g.42682C>Tvariant
SNP
  • missense variant
NC_001146.8:g.42839C>Avariant
SNP
  • missense variant
NC_001146.8:g.42185G>Avariant
SNP
  • synonymous variant
NC_001146.8:g.42589A>Cvariant
SNP
  • missense variant
NC_001146.8:g.42819A>Gvariant
SNP
  • missense variant
NC_001146.8:g.42977C>Gvariant
SNP
  • missense variant
NC_001146.8:g.43038G>Cvariant
SNP
  • missense variant
NC_001146.8:g.43100T>Cvariant
SNP
  • intergenic variant
NC_001146.8:g.42031G>Avariant
SNP
  • intergenic variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
42.1k42.2k42.3k42.4k42.5k42.6k42.7k42.8k42.9k43.0k

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

67 interactor genes based on 67 annotations
PHA2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ATG19Saccharomyces cerevisiae
protein
  • two hybrid
PMID:18719252
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CMK1Saccharomyces cerevisiae
protein
  • enzymatic study
PMID:16319894
RNA
DHH1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
RNA
HEK2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:18805955
RNA
NAB2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:19840948
protein
RSC4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
SSB2Saccharomyces cerevisiae
protein
  • biochemical
PMID:23332755
protein
SUA7Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37863410
protein
UBI4Saccharomyces cerevisiae
protein
  • pull down
PMID:38803224
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Genetic Interactions

PHA2 role
PHA2 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
APL3Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BAP2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
COA4Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
CTK1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
DOM34Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
DUN1Saccharomyces cerevisiae
unspecified role
dosage lethality (sensu BioGRID)
  • inviable
PMID:23050238
unspecified role
ECM1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ESBP6Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ETR1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
FCY1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
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