Gene

FIG4

Species
Saccharomyces cerevisiae
Symbol
FIG4
Name
Factor-Induced Gene
Synonyms
  • YNL325C
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in fungal-type vacuole membrane and nuclear periphery. Part of PAS complex. Used to study Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase).
SGD Description
Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45738:SF5
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFIG49 of 9YesYes   
Mus musculusFig49 of 9YesYes   
Rattus norvegicusFig49 of 9YesYes   
Danio reriofig4a6 of 9YesYes   
Drosophila melanogasterFIG49 of 9YesYes   
Caenorhabditis elegansfigo-19 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal chemical compound accumulation
abnormal mating projection morphology
abnormal protein/peptide distribution
abnormal sporulation
abnormal vacuolar morphology
absent invasive growth
decreased chemical compound accumulation
decreased competitive fitness
decreased filamentous growth
decreased mating efficiency
Showing 1 - 10 of 27 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
29.0k29.5k30.0k30.5k31.0k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
fig4-D469Nallele
fig4-Δ
  • fig4-delta
allele
Yes
fig4-1
  • fig4-G519R
allele
Yes
fig4-I59Tallele
Yes
NC_001146.8:g.29547A>Gvariant
SNP
  • missense variant
NC_001146.8:g.30578G>Avariant
SNP
  • synonymous variant
NC_001146.8:g.31190T>Cvariant
SNP
  • synonymous variant
NC_001146.8:g.29975A>Gvariant
SNP
  • synonymous variant
NC_001146.8:g.29320A>Cvariant
SNP
  • missense variant
NC_001146.8:g.30413C>Tvariant
SNP
  • synonymous variant
Showing 1 - 10 of 24 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
29.0k29.5k30.0k30.5k31.0kYNL325C_id001 (FIG4)YNL325C_id002 (FIG4)YNL324W_mRNA (YNL324W)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

130 interactor genes based on 159 annotations
FIG4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CPR3Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
RNA
DHH1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
FAB1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:19037259
protein
FAB1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:32583743
protein
FAB1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:19037259
protein
FAB1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:18653468
protein
FAB1Saccharomyces cerevisiae
protein
  • pull down
PMID:18653468
RNA
GIS2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:21232131
RNA
HEK2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:18805955
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Genetic Interactions

FIG4 role
FIG4 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ADO1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:19269370
unspecified role
ASF1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:19269370
unspecified role
ATG1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:19269370
unspecified role
ATG18Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
enhancer gene
ATG18Saccharomyces cerevisiae
enhanced gene
phenotypic enhancement (sensu BioGRID)
  • chemical compound accumulation
PMID:17699591
unspecified role
ATG32Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
AVT5Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:29674565
unspecified role
BAP3Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BCK1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BCK1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:29674565
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