Gene

PTP2

Species
Saccharomyces cerevisiae
Symbol
PTP2
Name
Protein Tyrosine Phosphatase
Synonyms
  • YOR208W
Biotype
protein coding gene
Automated Description
Enables protein tyrosine phosphatase activity. Involved in several processes, including cellular hyperosmotic response; negative regulation of cell integrity MAPK cascade; and pheromone response MAPK cascade. Is active in nucleus.
SGD Description
Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19134:SF509
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Danio rerioptpn182 of 9YesYes   
Caenorhabditis elegansT27A3.52 of 9YesYes   
Caenorhabditis elegansC17H12.32 of 9YesYes   
Caenorhabditis elegansF47B3.12 of 9YesYes   
Caenorhabditis elegansC33H5.162 of 9YesYes   
Caenorhabditis elegansC55B7.32 of 9YesYes   
Caenorhabditis elegansF36H12.102 of 9YesYes   
Caenorhabditis elegansZK354.82 of 9YesYes   
Caenorhabditis elegansK07F5.82 of 9YesYes   
Caenorhabditis elegansF47B3.62 of 9YesYes   
Caenorhabditis elegansZK484.72 of 9YesYes   
Caenorhabditis elegansZK616.652 of 9YesYes   
Caenorhabditis elegansF36H1.32 of 9YesYes   
Caenorhabditis elegansY48G9A.92 of 9YesYes   
Caenorhabditis elegansB0207.12 of 9YesYes   
Caenorhabditis elegansC02B10.62 of 9YesYes   
Caenorhabditis eleganspph-72 of 9YesYes   
Caenorhabditis elegansM04G7.22 of 9YesYes   
Caenorhabditis elegansT22C1.82 of 9YesYes   
Caenorhabditis elegansF10G8.12 of 9YesYes   
Caenorhabditis elegansF47B3.72 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal protein/peptide distribution
abnormal vacuolar morphology
decreased competitive fitness
decreased heat sensitivity
decreased resistance to chemicals
decreased resistance to enzymatic treatment
decreased toxin resistance
increased competitive fitness
increased filamentous growth
increased invasive growth
Showing 1 - 10 of 16 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
734.0k734.2k734.4k734.6k734.8k735.0k735.2k735.4k735.6k735.8k736.0k

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

95 interactor genes based on 149 annotations
PTP2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ADR1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:20489023
protein
ATG11Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
RNA
CAF20Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:25973932
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CDC28Saccharomyces cerevisiae
protein
  • enzymatic study
PMID:10580002
RNA
DHH1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
FXR2Homo sapiens
protein
  • two hybrid
PMID:27107014
protein
FXR2Homo sapiens
protein
  • two hybrid pooling approach
PMID:27107014
protein
FXR2Homo sapiens
protein
  • two hybrid array
PMID:27107014
RNA
HEK2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:18805955
Showing 1 - 10 of 37 rows
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Genetic Interactions

PTP2 role
PTP2 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
AAD3Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ACT1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ACT1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATP2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
suppressor gene
BCK1Saccharomyces cerevisiae
suppressed gene
dosage rescue (sensu BioGRID)
  • competitive growth, partial rescue
PMID:10523653
suppressor gene
BCK1Saccharomyces cerevisiae
suppressed gene
dosage rescue (sensu BioGRID)
  • vegetative growth
PMID:25736922
unspecified role
CAK1Saccharomyces cerevisiae
unspecified role
dosage lethality (sensu BioGRID)
  • inviable
PMID:10580002
unspecified role
CAK1Saccharomyces cerevisiae
unspecified role
synthetic rescue (sensu BioGRID)
  • heat sensitivity, partial rescue
PMID:10580002
unspecified role
CDC55Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:19269370
unspecified role
CFD1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
Showing 1 - 10 of 112 rows
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