Gene

snf-6

Species
Caenorhabditis elegans
Symbol
snf-6
Name
Sodium: Neurotransmitter symporter Family 6
Synonyms
  • CELE_M01G5.5
  • M01G5.5
Biotype
protein coding gene
Automated Description
Enables PDZ domain binding activity and acetylcholine transmembrane transporter activity. Involved in acetylcholine transport; choline transport; and positive regulation of locomotion. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; intestinal muscle; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14) and SLC6A5 (solute carrier family 6 member 5).
WB Description
snf-6 encodes a member of the sodium:neurotransmitter symporter family.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11616
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSLC6A52 of 9YesYes   
Homo sapiensSLC6A142 of 9YesYes   
Mus musculusSlc6a52 of 9YesYes   
Rattus norvegicusSlc6a52 of 9YesYes   
Xenopus tropicalisslc6a52 of 9YesYes   
Danio rerioslc6a52 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
snf-5176745263 of 8  
dat-1264352303 of 8  
mod-5363553312 of 8  
snf-11464951283 of 8  
snf-9570045273 of 8  
snf-7670247253 of 8  
snf-12771444253 of 8  
snf-2865547263 of 8  
snf-3956251282 of 8  
snf-101067441223 of 8  
snf-11167140232 of 8  
F56F4.31256439223 of 8  
Y43D4A.1134070422 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
amplitude of sinusoidal movement variant
backward point velocity increased
body posture amplitude decreased
body posture wavelength decreased
coiling frequency decreased
fat
forward point velocity increased
frequency of body bend variant
head bend angle variant
nose movement increased
Showing 1 - 10 of 13 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
1.520M1.522M1.524M1.526M1.528M1.530M1.532M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
eg28allele with one associated variant
point mutation
  • stop gained
YesYes
NC_003281.10:g.1527344T>Avariant
SNP
  • intron variant
NC_003281.10:g.1528091C>Tvariant
SNP
  • splice region variant
NC_003281.10:g.1531227G>Avariant
SNP
  • intron variant
NC_003281.10:g.1531707C>Tvariant
SNP
  • intron variant
NC_003281.10:g.1522486T>Cvariant
SNP
  • intron variant
NC_003281.10:g.1524856C>Tvariant
SNP
  • intron variant
NC_003281.10:g.1526175A>Cvariant
SNP
  • intron variant
NC_003281.10:g.1527284G>Avariant
SNP
  • intron variant
NC_003281.10:g.1527319C>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 258 rows
per page

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
BZ28WB
Showing 1 - 1 of 1 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.520M1.522M1.524M1.526M1.528M1.530M1.532MM01G5.5.1 (snf-6)M01G5.8M01G5.7

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 8 annotations
snf-6 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
dlg-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
protein
dlg-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
protein
dsh-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
protein
lin-7Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
protein
mpz-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
protein
stn-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:15318222
protein
stn-2Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:18711339
Showing 1 - 7 of 7 rows
per page

Genetic Interactions

snf-6 role
snf-6 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ace-1Caenorhabditis elegans
unspecified role
genetic interaction
    PMID:15318222
    Showing 1 - 1 of 1 rows
    per page