Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: response to UV
TP53
(Homo sapiens)Gene
Name: tumor protein p53
Synonyms: cellular tumor antigen p53, tumor supressor p53, BCC7, transformation-related protein 53, p53 transformation suppressor, antigen NY-CO-13, mutant tumor protein 53, P53, phosphoprotein p53, p53 antigen, FLJ92943, TRP53, mutant p53 protein, tumor protein 53, tumor suppressor TP53, tumor suppressor p53, LFS1, p53 tumor suppressor, BMFS5, truncated p53 protein
Source: HGNC:11998
Biotype: protein coding gene
Trp53
(Mus musculus)Gene
Name: transformation related protein 53
Synonyms: p44, p53
Source: MGI:98834
Biotype: protein coding gene
daf-2
(Caenorhabditis elegans)Gene
Name: abnormal DAuer Formation 2
Synonyms: Y55D5A.5, CELE_Y55D5A.5
Source: WB:WBGene00000898
Biotype: protein coding gene
BRCA2
(Homo sapiens)Gene
Name: BRCA2 DNA repair associated
Synonyms: truncated breast and ovarian cancer susceptibility protein 2, DNA repair-associated BRCA2, FAD1, truncated DNA repair-associated BRCA2, BRCC2, GLM3, BRCA2, DNA repair associated, BRCA1/BRCA2-containing complex, subunit 2, breast cancer type 2 susceptibility protein, breast cancer 2, early onset, breast cancer 2 tumor suppressor, breast and ovarian cancer susceptibility gene, early onset, PNCA2, truncated BRCA2 DNA repair associated, fanconi anemia group D1 protein, truncated breast cancer 2, FAD, mutant BRCA2, breast cancer susceptibility protein BRCA2, FANCB, FANCD, breast and ovarian cancer susceptibility protein 2, mutant DNA repair-associated protein 2, FANCD1, BROVCA2, XRCC11, breast cancer 2, FACD
Source: HGNC:1101
Biotype: protein coding gene
EGFR
(Homo sapiens)Gene
Name: epidermal growth factor receptor
Synonyms: PIG61, NNCIS, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR vIII, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40, erb-b2 receptor tyrosine kinase 1, ERRP, ERBB, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), erythroblastic leukemia viral (v-erb-b) oncogene homolog, ERBB1, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61, NISBD2, HER1
Source: HGNC:3236
Biotype: protein coding gene
TYR
(Homo sapiens)Gene
Name: tyrosinase
Synonyms: SHEP3, OCA1, tumor rejection antigen AB, LB24-AB, SK29-AB, OCA1A, oculocutaneous albinism IA, CMM8, ATN, OCAIA, monophenol monooxygenase
Source: HGNC:12442
Biotype: protein coding gene
MYC
(Homo sapiens)Gene
Name: MYC proto-oncogene, bHLH transcription factor
Synonyms: proto-oncogene c-Myc, avian myelocytomatosis viral oncogene homolog, c-Myc, MYCC, v-myc myelocytomatosis viral oncogene homolog, myc proto-oncogene protein, class E basic helix-loop-helix protein 39, transcription factor p64, bHLHe39, MRTL, cMyc, myc-related translation/localization regulatory factor, v-myc avian myelocytomatosis viral oncogene homolog
Source: HGNC:7553
Biotype: protein coding gene
ERCC5
(Homo sapiens)Gene
Name: ERCC excision repair 5, endonuclease
Synonyms: xeroderma pigmentosum, complementation group G, ERCC5-201, UVDR, ERCM2, xeroderma pigmentosum group G-complementing protein, XPG, COFS3, excision repair protein, excision repair cross-complementing rodent repair deficiency, complementation group 5, DNA repair protein complementing XP-G cells, excision repair cross-complementation group 5, XPG-complementing protein, DNA excision repair protein ERCC-5, XPGC, xeroderma pigmentosum complementation group G protein
Source: HGNC:3437
Biotype: protein coding gene
BCL2
(Homo sapiens)Gene
Name: BCL2 apoptosis regulator
Synonyms: Bcl-2, protein phosphatase 1, regulatory subunit 50, Bcl-2a, B-cell CLL/lymphoma 2, PPP1R50, Bcl-2ß, apoptosis regulator Bcl-2, b-cell leukemia/lymphoma 2, BCL2, apoptosis regulator
Source: HGNC:990
Biotype: protein coding gene
SIRT1
(Homo sapiens)Gene
Name: sirtuin 1
Synonyms: SIR2-like protein 1, NAD-dependent protein deacylase sirtuin-1, SIR2alpha, SIR2, sir2-like 1, sirtuin, SIR2L1, NAD-dependent protein deacetylase sirtuin-1, regulatory protein SIR2 homolog 1, hSIRT1, hSIR2, sirtuin type 1, NAD-dependent deacetylase sirtuin-1
Source: HGNC:14929
Biotype: protein coding gene
Cdkn1a
(Mus musculus)Gene
Name: cyclin dependent kinase inhibitor 1A
Synonyms: CDKI, Cip1, p21Cip1, P21, Cdkn1, p21, cyclin dependent kinase inhibitor, CIP1, UV96, p21WAF, Waf1, CAP20, SDI1, mda6
Source: MGI:104556
Biotype: protein coding gene
daf-16
(Caenorhabditis elegans)Gene
Name: abnormal DAuer Formation 16
Synonyms: daf-17, R13H8.1, CELE_R13H8.1
Source: WB:WBGene00000912
Biotype: protein coding gene
Mmp2
(Mus musculus)Gene
Name: matrix metallopeptidase 2
Synonyms: GelA, MMP-2, collagenase IVA, basement membrane, 72 kDa, gelatinase A, Clg4a, 72kDa type IV collagenase, 72kDa gelatinase
Source: MGI:97009
Biotype: protein coding gene
ERCC2
(Homo sapiens)Gene
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms: general transcription and DNA repair factor IIH helicase subunit XPD, TTD, TFIIH basal transcription factor complex 80 kDa subunit, TTD1, TFIIH basal transcription factor complex helicase subunit, COFS2, DNA 5'-3' helicase XPD, XPD, EM9, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein, BTF2 p80, basic transcription factor 2 80 kDa subunit, trichothiodystrophy, MGC102762, MGC126218, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex helicase XPB subunit, MGC126219, excision repair cross-complementation group 2, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH subunit XPD, TFIIH, CXPD, TFIIH p80, TFIIH 80 kDa subunit, DNA excision repair protein ERCC-2
Source: HGNC:3434
Biotype: protein coding gene
ATR
(Homo sapiens)Gene
Name: ATR serine/threonine kinase
Synonyms: FRAP-related protein 1, MEC1, ataxia telangiectasia and Rad3-related protein, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3 related, FRAP-related protein-1, FRP1, SCKL1, serine/threonine-protein kinase ATR, protein kinase ATR, SCKL, Rad3 related protein, FCTCS
Source: HGNC:882
Biotype: protein coding gene
MMP2
(Homo sapiens)Gene
Name: matrix metallopeptidase 2
Synonyms: matrix metalloproteinase-2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), TBE-1, CLG4, matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase), 72 kDa gelatinase, collagenase type IV-A, MONA, MMP-2, matrix metalloproteinase-II, CLG4A, gelatinase A, MMP-II, 72 kDa type IV collagenase, neutrophil gelatinase
Source: HGNC:7166
Biotype: protein coding gene
Tyr
(Mus musculus)Gene
Name: tyrosinase
Synonyms: skin/coat color 35, Oca1, c, albino, skc35
Source: MGI:98880
Biotype: protein coding gene
Brca2
(Mus musculus)Gene
Name: breast cancer 2, early onset
Synonyms: expressed sequence AW045498, AW045498, Fancd1, expressed sequence AI256696, AI256696, RAB163
Source: MGI:109337
Biotype: protein coding gene
Casp3
(Mus musculus)Gene
Name: caspase 3
Synonyms: RIKEN cDNA A830040C14 gene, Apopain, melody, CC3, A830040C14Rik, Yama, AC-3, CPP32, mldy, CPP32-beta, Lice, Caspase-3
Source: MGI:107739
Biotype: protein coding gene
XPA
(Homo sapiens)Gene
Name: XPA, DNA damage recognition and repair factor
Synonyms: XPAC, RP11-244N9.4, xeroderma pigmentosum, complementation group A, XP1, excision repair-controlling, DNA repair protein complementing XP-A cells, xeroderma pigmentosum group A-complementing protein, mutant xeroderma pigmentosum complementation group A
Source: HGNC:12814
Biotype: protein coding gene
AKT1
(Homo sapiens)Gene
Name: AKT serine/threonine kinase 1
Synonyms: serine-threonine protein kinase, PRKBA, protein kinase B alpha, v-akt murine thymoma viral oncogene homolog 1, PKB, CWS6, MGC99656, AKT, PKB-ALPHA, RAC-alpha serine/threonine-protein kinase, AKT1m, RAC, proto-oncogene c-Akt, rac protein kinase alpha, RAC-PK-alpha, RAC-ALPHA, protein kinase B, PKB alpha, v-akt murine thymoma viral oncogene-like protein 1
Source: HGNC:391
Biotype: protein coding gene
Bax
(Mus musculus)Gene
Name: BCL2-associated X protein
Synonyms: Not Available
Source: MGI:99702
Biotype: protein coding gene
p53
(Drosophila melanogaster)Gene
Name: p53
Synonyms: CG33336, CG10873, dp53, DMP53, Dp53, P53, prac, dmp53, D-p53, Dmp53, Dm-P53, DmP53, dmP53, protein 53, CG31325, p53-like regulator of apoptosis and cell cycle, Drosophila p53
Source: FB:FBgn0039044
Biotype: protein coding gene
STK11
(Homo sapiens)Gene
Name: serine/threonine kinase 11
Synonyms: serine/threonine-protein kinase STK11, polarization-related protein LKB1, renal carcinoma antigen NY-REN-19, serine/threonine kinase 11 (peutz-jeghers syndrome), liver kinase B1, serine/threonine-protein kinase 11, PJS, serine/threonine-protein kinase LKB1, hLKB1, LKB1
Source: HGNC:11389
Biotype: protein coding gene
Tp53
(Rattus norvegicus)Gene
Name: tumor protein p53
Synonyms: cellular tumor antigen p53, tumor protein p53 (Li-Fraumeni syndrome), Trp53, tumor suppressor p53, transformation related protein 53, MGC112612, p53
Source: RGD:3889
Biotype: protein coding gene
Sirt1
(Mus musculus)Gene
Name: sirtuin 1
Synonyms: Sir2, expressed sequence AA673258, AA673258, Sir2alpha
Source: MGI:2135607
Biotype: protein coding gene
Akt1
(Mus musculus)Gene
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, PKB, Akt, PKBalpha
Source: MGI:87986
Biotype: protein coding gene
MDM2
(Homo sapiens)Gene
Name: MDM2 proto-oncogene
Synonyms: oncoprotein Mdm2, HDMX, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MGC71221, Mdm2, p53 E3 ubiquitin protein ligase homolog, ACTFS, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, HDM2 transcript variant MYO-18, MGC5370, hdm2, HDM2 transcript variant MYO-32, HDM2 transcript variant MYO-4, HDM2 transcript variant MYO-24, ubiquitin-protein ligase E3 Mdm2, HDM2 transcript variant MYO-25, MDM2 oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, double minute 2, human homolog of, p53-binding protein, HDM2 transcript variant MYO-1, HDM2 transcript variant MYO-26, Mdm2 p53 binding protein homolog, HDM2 transcript variant MYO-20, MDM2 variant FB30, E3 ubiquitin-protein ligase Mdm2, double minute 2, human homolog of, LSKB
Source: HGNC:6973
Biotype: protein coding gene
CDKN1A
(Homo sapiens)Gene
Name: cyclin dependent kinase inhibitor 1A
Synonyms: DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1a, p21Cip1/Waf1, cyclin-dependent kinase inhibitor 1, p21CIP1, wild-type p53-activated fragment 1, melanoma differentiation-associated protein 6, P21, MDA-6, cyclin-dependent kinase inhibitor 1A (p21, Cip1), CIP1, CDK-interacting protein 1, CDK-interaction protein 1, WAF1, CDKN1, CAP20, melanoma differentiation associated protein 6, SDI1
Source: HGNC:1784
Biotype: protein coding gene
SPRTN
(Homo sapiens)Gene
Name: SprT-like N-terminal domain
Synonyms: DVC1, DDDL1880, C1orf124, Spartan, DNA damage-targeting VCP (p97) adaptor, protein with SprT-like domain at the N terminus, DKFZp547N043, zinc finger RAD18 domain-containing protein C1orf124, DNA damage protein targeting VCP, RJALS, RP5-876B10.3, dJ876B10.3, SprT-like domain at the N terminus, sprT-like domain-containing protein Spartan, PRO4323, DNA-dependent metalloprotease SPRTN
Source: HGNC:25356
Biotype: protein coding gene
tp53
(Danio rerio)Gene
Name: tumor protein p53
Synonyms: etID22686.5, brp53, drp53, fb40d06, zgc:111919, p53, wu:fb40d06
Source: ZFIN:ZDB-GENE-990415-270
Biotype: protein coding gene
CAT
(Homo sapiens)Gene
Name: catalase
Synonyms: MGC138422, MGC138424
Source: HGNC:1516
Biotype: protein coding gene
MAPK14
(Homo sapiens)Gene
Name: mitogen-activated protein kinase 14
Synonyms: stress-activated protein kinase 2A, p38 mitogen activated protein kinase, cytokine suppressive anti-inflammatory drug binding protein, SAPK2A, MAP kinase 14, Mxi2, MAX-interacting protein 2, p38, MAP kinase p38 alpha, CSPB1, mitogen-activated protein kinase p38 alpha, MAPK 14, p38ALPHA, CSAID-binding protein, CSBP, CSBP2, PRKM15, CSBP1, PRKM14, p38 MAP kinase, cytokine suppressive anti-inflammatory drug-binding protein, Csaids binding protein, p38alpha Exip, RK, EXIP, MAP kinase Mxi2
Source: HGNC:6876
Biotype: protein coding gene
MAPK8
(Homo sapiens)Gene
Name: mitogen-activated protein kinase 8
Synonyms: JNK1 alpha protein kinase, SAPK1c, JUN N-terminal kinase, JNK21B1/2, JNK, JNK1, stress-activated protein kinase JNK1, protein kinase JNK1, stress-activated protein kinase 1c, JNK1A2, MAP kinase 8, stress-activated protein kinase 1, mitogen-activated protein kinase 8 isoform JNK1 beta2, c-Jun N-terminal kinase 1, mitogen-activated protein kinase 8 isoform JNK1 alpha1, SAPK1, PRKM8, MAPK 8, JNK1 beta protein kinase, JNK-46
Source: HGNC:6881
Biotype: protein coding gene
Mettl3
(Mus musculus)Gene
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Synonyms: Spo8, 2310024F18Rik, M6A, RIKEN cDNA 2310024F18 gene
Source: MGI:1927165
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
Mc1r
(Mus musculus)Gene
Name: melanocortin 1 receptor
Synonyms: melanocyte hormone receptor alpha, extension, recessive yellow, Mcr1, Mshra, e, Tob, extension recessive yellow, tobacco darkening
Source: MGI:99456
Biotype: protein coding gene
xpa
(Danio rerio)Gene
Name: xeroderma pigmentosum, complementation group A
Synonyms: zgc:63640
Source: ZFIN:ZDB-GENE-040426-1205
Biotype: protein coding gene
Xpc
(Mus musculus)Gene
Name: xeroderma pigmentosum, complementation group C
Synonyms: Not Available
Source: MGI:103557
Biotype: protein coding gene
Ep300
(Mus musculus)Gene
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Source: MGI:1276116
Biotype: protein coding gene
FECH
(Homo sapiens)Gene
Name: ferrochelatase
Synonyms: protoheme ferro-lyase, ferrochelatase, mitochondrial, heme synthetase, EPP, heme synthase, FCE, EPP1, protoporphyria
Source: HGNC:3647
Biotype: protein coding gene
FBXW7
(Homo sapiens)Gene
Name: F-box and WD repeat domain containing 7
Synonyms: homolog of C elegans sel-10, FBX30, SEL-10, hCdc4, F-box protein SEL-10, F-box protein FBW7, archipelago homolog, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW6, FBW7, DEDHIL, FBXW6, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), AGO, SEL10, CDC4, FBXO30, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, hAgo, FLJ16457, archipelago, Drosophila, homolog of, F-box and WD-40 domain-containing protein 7, archipelago, DKFZp686F23254
Source: HGNC:16712
Biotype: protein coding gene
Bcl2
(Mus musculus)Gene
Name: B cell leukemia/lymphoma 2
Synonyms: Bcl-2, RIKEN cDNA D630044D05 gene, D630044D05Rik, D830018M01Rik, C430015F12Rik, RIKEN cDNA C430015F12 gene, RIKEN cDNA D830018M01 gene, expressed sequence AW986256, AW986256
Source: MGI:88138
Biotype: protein coding gene
EP300
(Homo sapiens)Gene
Name: E1A binding protein p300
Synonyms: p300, p300 HAT, MKHK2, KAT3B, histone butyryltransferase p300, histone acetyltransferase p300, E1A-binding protein, 300kD, RSTS2, E1A-associated protein p300, histone crotonyltransferase p300
Source: HGNC:3373
Biotype: protein coding gene
MAPK11
(Homo sapiens)Gene
Name: mitogen-activated protein kinase 11
Synonyms: P38BETA2, SAPK2B, MAPK 11, stress-activated protein kinase-2, P38B, mitogen-activated protein kinase p38-2, PRKM11, stress-activated protein kinase 2b, MAP kinase 11, p38Beta, stress-activated protein kinase 2, stress-activated protein kinase-2b, mitogen-activated protein kinase p38 beta, p38-2, SAPK2, MAP kinase p38 beta
Source: HGNC:6873
Biotype: protein coding gene
SIRT6
(Homo sapiens)Gene
Name: sirtuin 6
Synonyms: NAD-dependent protein deacylase sirtuin-6, regulatory protein SIR2 homolog 6, sirtuin, NAD-dependent deacetylase sirtuin-6, SIR2-like protein 6, sirtuin type 6, hSIRT6, NAD-dependent protein deacetylase sirtuin-6, SIR2L6, sir2-related protein type 6
Source: HGNC:14934
Biotype: protein coding gene
Fech
(Mus musculus)Gene
Name: ferrochelatase
Synonyms: expressed sequence AI894116, AI894116, fch, Fcl
Source: MGI:95513
Biotype: protein coding gene
PRKAA1
(Homo sapiens)Gene
Name: protein kinase AMP-activated catalytic subunit alpha 1
Synonyms: MGC57364, ACACA kinase, AMPK subunit alpha-1, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, tau-protein kinase PRKAA1, AMP-activated protein kinase, catalytic, alpha-1, AMPK, alpha, 1, 5'-AMP-activated protein kinase, catalytic alpha-1 chain, AMPK, AMPKa1, AMPK alpha 1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, MGC33776, AMP -activate kinase alpha 1 subunit
Source: HGNC:9376
Biotype: protein coding gene
WRN
(Homo sapiens)Gene
Name: WRN RecQ like helicase
Synonyms: RECQ3, RECQL3, Werner syndrome RecQ like helicase, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, Werner syndrome, RecQ helicase-like, recQ protein-like 2, exonuclease WRN, DNA helicase, RecQ-like type 3, DKFZp686C2056, RECQL2, Werner syndrome ATP-dependent helicase
Source: HGNC:12791
Biotype: protein coding gene
POLA1
(Homo sapiens)Gene
Name: DNA polymerase alpha 1, catalytic subunit
Synonyms: polymerase (DNA) alpha 1, catalytic subunit, DNA polymerase alpha catalytic subunit, polymerase (DNA directed), alpha 1, catalytic subunit, N syndrome (mental retardation, malformations, chromosome breakage), polymerase (DNA directed), alpha 1, p180, DNA polymerase alpha catalytic subunit p180, POLA, dna polymerase alpha subunit i, NSX, DKFZp686K1672, VEODS, DNA polymerase alpha p180 subunit, polymerase (DNA-directed), alpha (70kD), DNA polymerase alpha 1 catalytic subunit, PDR
Source: HGNC:9173
Biotype: protein coding gene